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10171832001

Roche

Aldehyde Dehydrogenase

from yeast

Synonym(s):

Aldehyde dehydrogenase

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About This Item

UNSPSC Code:
12352204
EC Number:
1.2.1.5 (BRENDA, IUBMB)
NACRES:
NA.54
Specific activity:
~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)
Biological source:
yeast
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biological source

yeast

form

lyophilized

specific activity

~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)

packaging

pkg of 250 U

manufacturer/tradename

Roche

optimum pH

8.75

relevant disease(s)

cancer

storage temp.

2-8°C

General description

Aldehyde dehydrogenase (ALDH) is a soluble enzyme and its activity depends on potassium ions and cysteine. The family of ALDH comprises of 19 genes in human. ALDH gene is expressed in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. ALDH is a component of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) recycling systems.

Application

Aldehyde Dehydrogenase has been used to evaluate fiber-optic biosensors for measurement of acetaldehyde (AcH) in liquid phase (AcH biosensor).

Biochem/physiol Actions

Aldehyde dehydrogenase (ALDH) regulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene are associated with Sjogren Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH takes part in the oxidation of aldehydes to acids. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.

Physical form

Enzyme is stabilized with potassium phosphate buffer, pH approximately 6.

Analysis Note

Contaminants: <0.01% “NADH oxidase”, ADH, and LDH each

Other Notes

For life science research only. Not for use in diagnostic procedures.

pictograms

Exclamation markHealth hazard
GHS07,GHS08

signalword

Warning

hcodes

H332,H373

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
85033223
85033222
77784022
77784021
56406039

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Yeast Aldehyde Dehydrogenase II. PROPERTIES OF THE HOMOGENEOUS ENZYME PREPARATIONS
Charles R. Steinman and WILLIAM B. JAKOBY
The Journal of Biological Chemistry, 243(4), 730-734 (1965)
Improved sensitivity of acetaldehyde biosensor by detecting ADH reverse reaction-mediated NADH fluoro-quenching for wine evaluation
Iitani K, et al.
ACS sensors, 2(7), 940-946 (2017)
Kenta Iitani et al.
Sensors (Basel, Switzerland), 23(13) (2023-07-14)
The molecule 2-nonenal is renowned as the origin of unpleasant human aging-related body odor that can potentially indicate age-related metabolic changes. Most 2-nonenal measurements rely on chromatographic analytical systems, which pose challenges in terms of daily usage and the ability
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Global Trade Item Number

SKUGTIN
1017183200104061838668455