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10652202001

Roche

Transferrin

from human serum

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Synonym(s):
serum glycoprotein, transferrin

Quality Level

100

sterility

0.2 μm filtered

form

solution

packaging

pkg of 20 mL (30 mg/ml)

manufacturer/tradename

Roche

technique(s)

cell culture | mammalian: suitable

color

clear red

solubility

water: miscible

UniProt accession no.

P02787

storage temp.

2-8°C

Gene Information

human ... TF(7018)

Related Categories

General description

Transferrin is a serum glycoprotein that participates in the transport of iron from absorption and storage sites to tissue cells. The iron-bound transferrin, also referred to as ferrotransferrin, binds to specific cell surface receptors on growing cells and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.

Application

Transferrin, similar to insulin, is a component of most serum-free media formulations. The main function of transferrin is to transport iron into cells by receptor-mediated endocytosis.
Transferrin from human serum has been used as a supplement in:
  • differentiation medium
  • keratinocyte medium
  • haemogenic endothelium culture medium
  • embryoid-body medium
  • blast colony forming cell-culture medium

Physical form

Solution, 30 mg/ml in IMDM, filtered through 0.2 μm pore size membrane. Iron saturation is below 1%. This product is Apo-Transferrin.

Preparation Note

Working concentration: 1 to 100 μg/ml

Storage and Stability

Store at 2 to 8 °C. (lyophilizate and solution)

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

No data available

Flash Point(C)

No data available

Regulatory Information

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Zhiru Guo et al.
Journal of visualized experiments : JoVE, (49)(49), doi:10-doi:10 (2011-04-15)
The homeostasis of all self-renewing tissues is dependent on adult stem cells. As undifferentiated stem cells undergo asymmetric divisions, they generate daughter cells that retain the stem cell phenotype and transit-amplifying cells (TA cells) that migrate from the stem cell
Iron deficiency affects early stages of embryonic hematopoiesis but not the
endothelial to hematopoietic transition.
Shvartsman M, et al.
bioRxiv (2018)
Özge Vargel et al.
Scientific reports, 6, 21518-21518 (2016-02-20)
The endothelial to haematopoietic transition (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to the formation of blood stem and progenitor cells during embryogenesis. As TGFβ signalling triggers a similar event during embryonic
Quantification of Mouse Hematopoietic Progenitors? Formation Using Time-lapse Microscopy and Image Analysis
Bergiers I, et al.
Bio-protocol, 9(1), e3137-e3137 (2019)
A Dautry-Varsat et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(8), 2258-2262 (1983-04-01)
At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to
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