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Roche

Adenosine 5′-triphosphate disodium salt trihydrate

=99%, pkg of 1 g (10519979001), pkg of 5 g (10519987001)

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Synonym(s):
ATP
Empirical Formula (Hill Notation):
C10H20N5Na2O16P3
CAS Number:
51963-61-2
Molecular Weight:
605.19
MDL number:
MFCD00150754
PubChem Substance ID:
329773088

Quality Level

100

description

Disodium salt

Assay

99%

form

crystals

mol wt

507.2 (ATP)
Mr 551.14 (ATP-Na2)

packaging

pkg of 1 g (10519979001)
pkg of 5 g (10519987001)

manufacturer/tradename

Roche

storage temp.

2-8°C

SMILES string

O.O.O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.3H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;3*1H2/q;2*+1;;;/p-2/t4-,6-,7-,10-;;;;;/m1...../s1

InChI key

MWEQTWJABOLLOS-AZGWGOJFSA-L

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General description

The special quality of ATP contains highly purified Adenosine-5′-triphosphate in crystal form.

Application

Adenosine 5′-triphosphate disodium salt trihydrate has been used:

  • in analyzing the ATP turnover cycle of microtubule motors
  • for activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome to perform in vitro stimulation of bone marrow-derived dendritic cells (BMDCs)
  • for in vitro ubiquitination
It is also suitable for the luminometric determination of luciferase (Luc) activity in cell extracts.

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a key energy currency, with high phosphate transfer potential, in all living organisms. ATP participates in several biological processes such as membrane transport, muscle contraction and synthesis, and degradation of biological molecules. It serves as an intracellular and extracellular signaling molecule in certain cellular processes such as cell motility, organ development, neurotransmission, and insulin secretion. Adenosine 5′-triphosphate (ATP) acts as a substrate for proteins of the kinesin superfamily.

Preparation Note

Storage conditions (working solution): The reconstituted aqueous solution is stable at 2 to 8 °C for one week.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling
Ullah, et al.
Cell Reports, 39 (2022)
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Nature Communications, 11 (2020)
The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones
Dahiya, et al.
Molecular Cell, 82, 1543-1556 (2022)
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Zhang, et al.
Science immunology, 7 (2022)

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