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DCTP-RO

Roche

dCTP

Name: dCTP
Brand: ROCHE

99% (dNTP), <0.9% (dNDP), solution, 100 mM

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Synonym(s):

2′-Deoxycytidine 5′-triphosphate disodium salt, dCTP-Na₂

Empirical Formula (Hill Notation):

C₉H₁₄N₃Na₂O₁₃P₃

CAS Number:

102783-51-7

Molecular Weight:

511.12

MDL number:

MFCD00084683

PubChem Substance ID:

329798916

description

PCR Grade, sodium salt

Quality Level

100

Assay

99% (dNTP)

form

solution

usage

sufficient for 125,000 standard reactions (03732690001)
sufficient for 31,250 standard reactions (11969021001)
sufficient for 6,250 standard reactions (11934520001)

packaging

pkg of 1,250 μL (11969021001 [100 mM])
pkg of 4 × 1,250 μL (03732690001 [4x100 mM])
pkg of 250 μL (11934520001 [100 mM])

manufacturer/tradename

Roche

concentration

<0.9% (dNDP)
100 mM

storage temp.

−20°C

SMILES string

[Na+].[Na+].NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O2

InChI

1S/C9H16N3O13P3.2Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17);;/q;2*+1/p-2/t5-,6+,8+;;/m0../s1

InChI key

ABWVCNMFYVEBIB-CDNBRZBRSA-L

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PCR Reagents & Kits

Roche® Life Science Products

General description

dCTP, PCR Grade, is a 100 mM clear colorless solution of the sodium salt (pH 8.3). PCR Grade nucleotides from Roche are specially manufactured and purified to the highest possible chemical purity. PCR Grade nucleotides contain at least 99% of the relevant deoxynucleoside-triphosphate (dNTP) and less than 0.9% deoxynucleoside-diphosphate (dNDP).

Application

2′-Deoxycytidine 5′-triphosphate disodium salt is one of the nucleoside triphosphates used for DNA polymerase driven reactions such as polymerase chain reaction, DNA sequencing and other molecular biology methods.

Quality

Function tested in RT-PCR. Tested for absence of contaminating deoxyribonucleases, ribonucleases and nicking activities according to the current Quality Control procedures.

Physical form

solution of dCTP in water (pH 8.3).

Preparation Note

Working solution: We recommend to prepare a deoxynucleotide mix containing dATP, dCTP, dGTP, dTTP (10 mM, each); (e.g., for the preparation of 100 μl nucleotide mix add 10 μl of dATP, dCTP, dGTP, dTTP (each) to 60 μl Water, PCR Grade).

Other Notes

For general laboratory use.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.

Mahir Karababa et al.

Antimicrobial agents and chemotherapy, 48(8), 3064-3079 (2004-07-27)

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Alix T Coste et al.

Eukaryotic cell, 3(6), 1639-1652 (2004-12-14)

The ABC transporter genes CDR1 and CDR2 can be upregulated in Candida albicans developing resistance to azoles or can be upregulated by exposing cells transiently to drugs such as fluphenazine. The cis-acting drug-responsive element (DRE) present in the promoters of

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.

Xiangang Zong et al.

Pflugers Archiv : European journal of physiology, 458(5), 891-899 (2009-06-27)

Second messenger-induced Ca(2+)-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP(3)), Ca(2+), and cyclic ADP ribose (cADPR) that trigger Ca(2+)-release from the endoplasmatic reticulum (ER), nicotinic acid adenine dinucleotide

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