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POLYDIC-RO

Roche

Poly[d(I-C)]

lyophilized, pkg of 10 U (10108812001 [A<sub>260</sub> units]), pkg of 50 U (11219847001 [A<sub>260</sub> units])

Synonym(s):

Poly-deoxy-inosinic-deoxy-cytidylic acid

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.54

Key Documents

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Product Name

Poly[d(I-C)], lyophilized, pkg of 10 U (10108812001 [A<sub>260</sub> units]), pkg of 50 U (11219847001 [A<sub>260</sub> units])

description

Poly-deoxy-inosinic-deoxy-cytidylic acid

form

lyophilized

mol wt

28814 bp

packaging

pkg of 10 U (10108812001 [A<sub>260</sub> units])
pkg of 50 U (11219847001 [A<sub>260</sub> units])

manufacturer/tradename

Roche

color

white

mp

54 °C (NaCl, 0.1 M, pH 7.0)

solubility

water: soluble

absorbance ratio

A290/260 nm 0.24-0.32
A280/260 nm 0.61-0.67
A250/260 nm 1.18-1.30

storage temp.

−20°C

Quality Level

100

Related Categories

Analysis Note

Typical analysis:
Absorbance determination A250/A260, A280/A260, A290/A260

Application

Poly[d(I-C)] is used as a template for RNA polymerases, and as a DNA model for biophysical investigations.
It is also used as a primer template with Kornberg DNA polymerase for the determination of small amounts of dITP, dGTP, and dCTP. Poly(dI-dC) has been used in electrophoretic mobility shift assays (EMSA).

Features and Benefits

Contents
Lyophilizate, sodium salt, base ratio 1:1, alternating base sequence

Other Notes

1 A260 unit corresponds to 50 μg ds DNA.

Unit Conversion: 1 A260 unit corresponds to 50 μg ds DNA.
Chain Length approx. 20,000 bp
For life science research only. Not for use in diagnostic procedures.
In an aqueous solution the DNA itself is a salt (the acid groups of the phosphate back bone have a negative charge and are saturated by positive sodium ions) i.e. there is no additional salt in solution. The structural formula which shows the negative 0-groups in the phosphate backbone is available. The same number of positive sodium ions must be dissociated in solution as counter ions.

As the sodium ions are part of the product and saturate the phosphate groups, the lyophilisate is salt-free.

Preparation Note

Activator: Polymines (spermine, spermidine)
Storage conditions (working solution): Solution is stable to at least 12 months if stored at 2 to 8 °C, contact with DNase or bacteria is to avoid.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
54824020
43501122
43501120
29874921
11746123

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Carlos Farkas et al.
PloS one, 8(9), e73817-e73817 (2013-09-17)
SALL2- a member of the Spalt gene family- is a poorly characterized transcription factor found deregulated in various cancers, which suggests it plays a role in the disease. We previously identified SALL2 as a novel interacting protein of neurotrophin receptors

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