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00942

Supelco

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane

for GC derivatization, LiChropur, ≥95.0% (GC)

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Synonym(s):
N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, MTBSTFA + 1% TBDMSCl, Silylating mixture VI
Empirical Formula (Hill Notation):
C9H18F3NOSi
CAS Number:
Molecular Weight:
241.33
Beilstein:
3606546
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

Assay

≥95.0% (GC)

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

impurities

0.5-1.5% tert-butyldimethylchlorosilane

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

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General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamidewith 1% tert-Butyldimethylchlorosilane (TBDMS) is a derivatizing reagentcommonly used in gas chromatography (GC) and gas chromatography-massspectrometry (GC-MS).

Application

MTBSTFA + 1% TBDMSCl can be used as a derivatizing reagentin the analysis of:
  • Organic acid profile in human serum by gaschromatography/mass spectrometry (GC/MS).
  • Nerveagents and their breakdown products by GC–MS-MS method.

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

113.0 °F - closed cup

Flash Point(C)

45 °C - closed cup

Regulatory Information

危险化学品

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Mass spectrometry of anabolic steroids as their tert-butyldimethylsilyl ether derivatives.
Steffenrud, S.
Rapid Communications in Mass Spectrometry, 10, 1698-1702 (1996)
Gas chromatography/mass spectrometry analysis of organic acid profiles in human serum: A protocol of direct ultrasound-assisted derivatization
Zhang MJ, et al.
Rapid Communications in Mass Spectrometry, 35(17), e9149-e9149 (2021)
The Application of a single-column GC--MS-MS method for the rapid analysis of chemical warfare agents and breakdown products
Young SA, et al.},
Journal of Analytical Toxicology, 43(3), 179-187 (2019)
Tsubasa Nakajima et al.
Plant & cell physiology, 55(9), 1605-1612 (2014-06-28)
Cyanobacteria have flexible metabolic capability that enables them to adapt to various environments. To investigate their underlying metabolic regulation mechanisms, we performed an integrated analysis of metabolic flux using transcriptomic and metabolomic data of a cyanobacterium Synechocystis sp. PCC 6803
Xue Shi et al.
Journal of proteome research, 14(2), 1174-1182 (2015-01-17)
The interactions among the gut, liver, and immune system play an important role in liver disease. Probiotics have been used for the treatment and prevention of many pathological conditions, including liver diseases. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF

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