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00942

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

Name: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Brand: SIAL

for GC derivatization, LiChropur^™, ≥95.0% (GC), with 1% tert-Butyldimethylchlorosilane

Synonym(s):

N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, MTBSTFA + 1% TBDMSCl, Silylating mixture VI

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₈F₃NOSi

CAS Number:

77377-52-7

Molecular Weight:

241.33

UNSPSC Code:

41116105

PubChem Substance ID:

329747171

NACRES:

NA.22

Beilstein/REAXYS Number:

3606546

MDL number:

MFCD00009671

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Properties

Product Name

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, LiChropur^™, ≥95.0% (GC)

grade

derivatization grade ((GC derivatization))

Quality Level

100

assay

≥95.0% (GC)

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

impurities

0.5-1.5% tert-butyldimethylchlorosilane

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

Description

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamidewith 1% tert-Butyldimethylchlorosilane (TBDMS) is a derivatizing reagentcommonly used in gas chromatography (GC) and gas chromatography-massspectrometry (GC-MS).

Application

MTBSTFA + 1% TBDMSCl can be used as a derivatizing reagentin the analysis of:

Organic acid profile in human serum by gaschromatography/mass spectrometry (GC/MS).
Nerveagents and their breakdown products by GC–MS-MS method.

Other Notes

Discover LiChropur^™ reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS02,GHS07

signalword

Warning

hcodes

H226,H315,H319

pcodes

P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

Regulatory Information

危险化学品

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Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

The Application of a single-column GC--MS-MS method for the rapid analysis of chemical warfare agents and breakdown products

Young SA, et al.},

Journal of Analytical Toxicology, 43(3), 179-187 (2019)

Gas chromatography/mass spectrometry analysis of organic acid profiles in human serum: A protocol of direct ultrasound-assisted derivatization

Zhang MJ, et al.

Rapid Communications in Mass Spectrometry, 35(17), e9149-e9149 (2021)

Mass spectrometry of anabolic steroids as their tert-butyldimethylsilyl ether derivatives.

Steffenrud, S.

Rapid Communications in Mass Spectrometry, 10, 1698-1702 (1996)

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Global Trade Item Number

SKU	GTIN
00942-1ML	04061838608482
00942-10X1ML	04061837683183
00942-1ML-KC	04061837683190
00942-10ML	04061838608475