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04238

Sigma-Aldrich

Hydroxyapatite

puriss., meets analytical specification of Ph. Eur., BP, FCC, E341, ≥90% (calculated on glowed substance)

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Synonym(s):
Calcium phosphate hydroxide, Durapatite, Hydroxylapatite
Linear Formula:
3Ca3(PO4)2 · Ca(OH)2
CAS Number:
Molecular Weight:
502.31
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

puriss.

Quality Level

Assay

≥90% (calculated on glowed substance)

form

powder

quality

meets analytical specification of Ph. Eur., BP, FCC, E341

composition

Ca, 35-40%

impurities

residual solvents, complies
≤0.001% heavy metals (as Pb)
≤0.2% insoluble in HCl

loss

≤8% loss on ignition, 800 °C

anion traces

chloride (Cl-): ≤1500 mg/kg
fluoride (F-): ≤50 mg/kg
sulfate (SO42-): ≤5000 mg/kg

cation traces

As: ≤2 mg/kg
Cd: ≤1 mg/kg
Cu: ≤20 mg/kg
Fe: ≤400 mg/kg
Hg: ≤1 mg/kg
Pb: ≤2 mg/kg
Zn: ≤20 mg/kg

SMILES string

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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P Ducheyne et al.
Biomaterials, 7(2), 97-103 (1986-03-01)
Hydroxyapatite from two sources was electrophoretically deposited onto flat titanium plate material. Depending upon the deposition conditions various changes in the structure of the ceramic were identified. A well-adhering Ti-P compound was present at the interface. Hydroxyapatite oxygenated to various
Mechanical properties of sintered hydroxyapatite for prosthetic applications.
Akao M ,et al.
J. Mater. Sci., 16(3), 809-812 (1981)
Chemical characterization of silicon-substituted hydroxyapatite
Gibson I, et al.
Journal of Biomedical Materials Research, 44(4), 422-428 (1999)
Bjarke Viberg et al.
Acta orthopaedica, 84(3), 254-259 (2013-04-19)
Elderly patients with displaced femoral neck fractures are commonly treated with a hemiarthroplasty (HA), but little is known about the long-term failure of this treatment. We compared reoperation rates for patients aged at least 75 years with displaced femoral neck
Sören Toksvig-Larsen et al.
Acta orthopaedica, 84(3), 314-318 (2013-04-30)
External fixation pins tend to loosen with time, especially from cancellous bone. A coating that releases a bisphosphonate has been shown to improve the fixation of dental implants in humans. We now tested a bisphosphonate coating on steel pins for

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