04635
Metformin hydrochloride
pharmaceutical secondary standard; traceable to USP and PhEur
Synonym(s):
1,1-Dimethylbiguanide hydrochloride, Metformin
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About This Item
Linear Formula:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
CAS Number:
Molecular Weight:
165.62
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
214-230-6
MDL number:
eCl@ss:
25140904
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. M0605000, traceable to USP 1396309
mp
223-226 °C (lit.)
application(s)
clinical testing
format
neat
storage temp.
2-8°C
SMILES string
Cl[H].CN(C)C(=N)NC(N)=N
InChI
1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI key
OETHQSJEHLVLGH-UHFFFAOYSA-N
Gene Information
—
Biochem/physiol Actions
Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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