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05238

Erythromycin A enol ether

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C37H65NO12
CAS Number:
33396-29-1
Molecular Weight:
715.91
NACRES:
NA.24
UNSPSC Code:
41116107
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grade

analytical standard

Quality Level

100

assay

≥95% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H](C3O)N(C)C)[C@@]4(C)CC(C)=C(O4)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

JFVYXJKGJMUGRG-KJPZRSJGSA-N

General description

Erythromycin A enol ether (EAEN) is an acidic degradation product of erythromycin A (EA) which is grouped under the macrolide antibiotic class of compounds.

Application

EAEN has been used for the analysis of EAEN as degradation product of EA in honey by ultra-performance liquid chromatography equipped with tandem quadrupole mass spectrometer (UPLC-MS/MS) with positive electrospray ionisation (ESI) operating on multiple reaction monitoring (MRM) mode and in rat′s blood plasma, serum and human urine by high performance liquid chromatography-coulometric assay. It may be used as a reference standard for the detection of EAEN in erythromycin fractions by isocratic LC with evaporative light scattering detection (ELSD) and ion trap MS and in commercial erythromycin samples by LC-MS/MS.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL0372
BCCF0025
BCBZ4501
BCBW1058
BCBT9997

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Determination of erythromycin and related substances in commercial samples using liquid chromatography/ion trap mass spectrometry.
Deubel A, et al.
Journal of Chromatography A, 1136(1), 39-47 (2006)
Y Shiba et al.
Gastroenterology, 110(1), 241-250 (1996-01-01)
EM523, a nonpeptide motilin agonist, is being developed for clinical use to improve delayed gastric emptying. The aim of this study was to examine the effect of EM523 on endogenous release of gut and pancreatic hormones in conscious dogs. Motility
Identification of impurities in erythromycin by liquid chromatography-mass spectrometric detection.
Chitneni SK, et al.
Journal of Chromatography A, 1056(1-2), 111-120 (2004)
View All Related Papers

Global Trade Item Number

SKUGTIN
A45009-5G04061832995274
1013046-35MG04061833019719
PHR2008-50MG04061835238446
A035004004061833327654
05238-5MG04061834034858