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05292

Sigma-Aldrich

Spermidine 0.1 M solution

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Synonym(s):
Spermidine solution, Additive Screening Solution 30/Kit-No 78374
CAS Number:
124-20-9
MDL number:
MFCD00008229
PubChem Substance ID:
329747679
NACRES:
NA.32

Quality Level

100

density

1.00 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Gene Information

mouse ... Odc1(18263)
rat ... Ppm1a(24666)

Biochem/physiol Actions

Spermidine is a naturally occurring polyamine. It is associated with various cellular functions. It is responsible for the condensation and aggregation of DNA in aqueous solution. Spermidine is known to extend lifespan via epigenetic modifications, induction of cell death and inhibition of necrosis.
Spermidine 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Satyanarayana U
Biochemistry (2014)
53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) and National Meeting of Chemistry of Biological Systems ? Italian Chemical Society (SCI - Section CSB) (2008)
Induction of autophagy by spermidine promotes longevity.
Eisenberg T et al.
Nature Cell Biology, 11, 1305-1305 (2009)
Marjorie Catala et al.
Bio-protocol, 10(12), e3646-e3646 (2021-03-05)
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In addition, functions of tRNAs are often modulated
Lluís Millan-Ariño et al.
Current protocols in protein science, 102(1), e114-e114 (2020-10-01)
Histones are the major proteinaceous component of chromatin in eukaryotic cells and an important part of the epigenome, affecting most DNA-related events, including transcription, DNA replication, and chromosome segregation. The properties of histones are greatly influenced by their post-translational modifications
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