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Merck
CN

06735

tert-Butyldimethylsilyl chloride

LiChropur™, ≥99.0% (GC)

Synonym(s):

tert-Butyl(chloro)dimethylsilane, tert-Butyldimethylchlorosilane, TBDMSCl

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About This Item

Linear Formula:
(CH3)3CSi(CH3)2Cl
CAS Number:
18162-48-6
Molecular Weight:
150.72
UNSPSC Code:
41116105
NACRES:
NA.22
PubChem Substance ID:
329748269
EC Number:
242-042-4
Beilstein/REAXYS Number:
505999
MDL number:
MFCD00000501

Key Documents

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Product Name

tert-Butyldimethylsilyl chloride, LiChropur™, ≥99.0% (GC)

SMILES string

CC(C)(C)[Si](C)(C)Cl

InChI key

BCNZYOJHNLTNEZ-UHFFFAOYSA-N

InChI

1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3

grade

derivatization grade ((GC derivatization))

assay

≥99.0% (GC)

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

bp

125 °C (lit.)

mp

86-89 °C (lit.)

Quality Level

100

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Other Notes

Discover LiChropur™ reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Flam. Sol. 1 - Skin Corr. 1A

Storage Class

4.1B - Flammable solid hazardous materials

wgk

WGK 2

flash_point_f

71.6 °F - closed cup

flash_point_c

22 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1883
BCBW0867
BCCB4665
BCBZ9530
BCBT6588

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Some observations on the t-butyldimethylchlorosilane derivatization reaction.
K Bricknell et al.
Biochemical medicine, 23(1), 119-121 (1980-02-01)
Hiroaki Wakimoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 2898-2909 (2014-04-10)
Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas. We prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections into mouse brains and
P Huttenloch et al.
Environmental science & technology, 35(21), 4260-4264 (2001-11-23)
The efficacy of the surface modification of natural diatomite and zeolite material by chlorosilanes is demonstrated. Chlorosilanes used were trimethylchlorosilane (TMSCI), tert-butyldimethylchlorosilane (TBDMSCI), dimethyloctadecylchlorosilane (DMODSCI), and diphenyldichlorosilane (DPDSCI) possessing different headgroups and chemical properties. Silanol groups of the diatomite and
Rie Harboe Nielsen et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(7), 694-698 (2014-08-12)
The classic form of Ehlers-Danlos syndrome (cEDS) is an inherited connective tissue disorder, where mutations in type V collagen-encoding genes result in abnormal collagen fibrils. Thus the cEDS patients have pathological connective tissue morphology and low stiffness, but the rate
C Tellis et al.
Journal of biochemistry, 119(4), 823-827 (1996-04-01)
1-O-Hexadecyl-2-acetyl-sn-glycerol, the immediate precursor of platelet- activating factor (PAF) in its de novo formation, was detected in the protozoon Tetrahymena pyriformis. It was purified from the total lipid extract by TLC, after successive developments in two different solvent systems. Characterization
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