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07596

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Sodium butyrate

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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Synonym(s):
Butyric acid sodium salt
Linear Formula:
CH3CH2CH2COONa
CAS Number:
156-54-7
Molecular Weight:
110.09
Beilstein:
3629439
EC Number:
205-857-6
MDL number:
MFCD00002816
PubChem Substance ID:
329748485
NACRES:
NA.24

grade

certified reference material
TraceCERT®

Quality Level

300

product line

TraceCERT®

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

storage condition

under inert gas (Argon)

mp

250-253 °C (lit.)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

InChI key

MFBOGIVSZKQAPD-UHFFFAOYSA-M

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General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

Application

Sodium butyrate is a sodium salt of butyric acid, with potent anticancer activity. It can act like a histone deacetylase inhibitor and it is known to influence the gene expression and differentiation in many cell lines.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 - H315 - H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Fight Cancer with Vitamins and Supplements: A Guide to Prevention and Treatment (2001)
Sodium Butyrate Induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1in p53-Independent manner.
Xiao H, et al.
Biochemical and Biophysical Research Communications, 237(2), 457-460 (1997)
Jing Jiang et al.
Scientific reports, 5, 9191-9191 (2015-03-18)
Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory mechanism of the epithelial barrier function has not been fully understood. This study aims to elucidate the role of the TWIK-related potassium channel-1 (Trek1) in the
Youngmi Cho et al.
Experimental biology and medicine (Maywood, N.J.), 239(3), 302-310 (2014-02-06)
DNA methylation and histone acetylation contribute to the transcriptional regulation of genes involved in apoptosis. We have demonstrated that docosahexaenoic acid (DHA, 22:6 n-3) and butyrate enhance colonocyte apoptosis. To determine if DHA and/or butyrate elevate apoptosis through epigenetic mechanisms thereby
Anastasia Gelgor et al.
Journal of virology, 89(10), 5298-5307 (2015-03-06)
The Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 16 (orf16) encodes a viral Bcl-2 (vBcl-2) protein which shares sequence and functional homology with the Bcl-2 family. Like its cellular homologs, vBcl-2 protects various cell types from apoptosis and can also
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