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Merck
CN

08982

Sodium metabisulfite

analytical standard

Synonym(s):

E223, Sodium disulfite, Sodium pyrosulfite

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About This Item

Linear Formula:
Na2S2O5
CAS Number:
Molecular Weight:
190.11
E Number:
E223
PubChem Substance ID:
UNSPSC Code:
85151701
NACRES:
NA.24
EC Number:
231-673-0
MDL number:
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Product Name

Sodium metabisulfite, analytical standard

InChI key

HRZFUMHJMZEROT-UHFFFAOYSA-L

InChI

1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2

SMILES string

[Na+].[Na+].[O-]S(=O)S([O-])(=O)=O

grade

analytical standard

assay

≥98.0% (iodometric, RT)

shelf life

limited shelf life, expiry date on the label

mp

>300 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
thiosulfate (S2O32-): ≤500 mg/kg

cation traces

As: ≤0.5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

Quality Level

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Analysis Note

metal trace analysis: corresponds to requirements

Application

Sodium metabisulfite may be used as an antioxidant which when added to anesthetic formulations serves to minimize epinephrine oxidation in the quantification of epinephrine in dental anesthetic solutions by capillary electrophoresis. Sodium metabisulfite may also be used as a standard in the determination of catecholamines in human plasma by high-performance liquid chromatography with electrochemical detection.

General description

Sodium metabisulfite is primarily used as an antioxidant and antimicrobial agent in a wide variety of foods and drugs. It is also used as the main additive in the prevention of melanosis in shrimp.

pictograms

CorrosionExclamation mark

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

supp_hazards

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Determination of catecholamines in human plasma by high-performance liquid chromatography with electrochemical detection.
Raggi MA, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 730(2), 201-211 (1999)
Quantitative assay for epinephrine in dental anesthetic solutions by capillary electrophoresis.
Kranack A and Chen DY
Analyst, 123(7), 1461-1463 (1998)
The molecular mechanisms of sodium metabisulfite on the expression of KATP and L-Ca2+ channels in rat hearts.
Zhang Q, et al.
Regulatory Toxicology and Pharmacology, 72(3), 440-446 (2015)
Standardization of sodium metabisulfite solution concentrations and immersion time for farmed shrimp Litopenaeus vannamei.
Andrade LTD, et al.
Ciencia Rural, 45(3), 499-504 (2015)
Jeffrey N Hemenway et al.
Journal of pharmaceutical sciences, 101(9), 3305-3318 (2012-05-23)
A 2,4-dinitrophenylhydrazine (DNPH) precolumn derivatization high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed to quantify levels of formaldehyde and acetaldehyde in polyethylene glycol (PEG) solutions. Formic acid and acetic acid were quantified by HPLC-UV. Samples of neat and aqueous PEG

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