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Potassium antimonyl tartrate trihydrate

Name: Potassium antimonyl tartrate trihydrate
Brand: SIAL

99.0-103.0%, powder, puriss., meets analytical specification of USP

Synonym(s):

Antimony potassium tartrate trihydrate, Tartar emetic

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About This Item

Empirical Formula (Hill Notation):

C₈H₄K₂O₁₂Sb₂ · 3H₂O

CAS Number:

28300-74-5

Molecular Weight:

667.87

NACRES:

NA.21

PubChem Substance ID:

57646885

UNSPSC Code:

12352100

EC Number:

234-293-3

MDL number:

MFCD00167056

Assay:

99.0-103.0%

Form:

powder

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Properties

Product Name

Potassium antimonyl tartrate trihydrate, puriss., meets analytical specification of USP, 99.0-103.0%, powder

Quality Level

200

grade

puriss.

assay

99.0-103.0%

form

powder

quality

meets analytical specification of USP

impurities

≤0.02 mmol/g free acid, ≤0.02 mmol/g free alkali

loss

≤2.7% loss on drying, 105 °C

mp

≥300 °C (lit.)

cation traces

As: ≤150 mg/kg, Pb: ≤20 mg/kg

SMILES string

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI key

WBTCZEPSIIFINA-UHFFFAOYSA-J

Description

General description

Potassium antimonyl tartrate trihydrate is a trivalent antimonial compound. It has been reported to be more toxic than pentavalent antimony (Pentostam) against Leishmania species. Its crystal structure has been investigated by the three-dimensional X-ray and white radiation neutron diffraction techniques. It crystallizes in space group C222₁. Unit cell dimensions reported were: a = 11.192(2), b = 11.696(3), and c = 25.932(5)Å.

Application

Potassium antimonyl tartrate trihydrate was employed as an Sb(III)-containing drug to investigate its ability to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum†
It may also be used as a standard solution to determine the metalloid concentration such as Sb(III) and Sb(V) in surface soil, using high performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (HPLC-ICP-MS).

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pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H315,H317,H332,H411

pcodes

P261 - P273 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

危险化学品

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"A study of antimony complexed to soil-derived humic acids and inorganic antimony species along a Massachusetts highway"

Ceriotti G and Amarasiriwardena D

Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 91(01), 85-93 (2009)

Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes.

D Sereno et al.

Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)

The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several

Axenically grown amastigotes of Leishmania infantum used as an in vitro model to investigate the pentavalent antimony mode of action.