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Merck
CN

15256

BSA+TMCS

derivatization grade (GC derivatization), LiChropur™, 93.0-97.0% (GC)

Synonym(s):

Bis(trimethylsilyl)acetamide + Trimethylchlorosilane

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About This Item

UNSPSC Code:
41116105
NACRES:
NA.22
PubChem Substance ID:
24849236

Key Documents

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grade

derivatization grade (GC derivatization)

assay

93.0-97.0% (GC)

quality

LiChropur™

composition

trimethylchlorosilane (minor component), 3.0-5.0% GC

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

Quality Level

100

Related Categories

General description

BSA+TMCS combination, is one of the most commonly used silylating reagents. BSA is readily used for silylating a wide range of functional groups such as non-sterically hindered alcohols, amides, amines, amino acids, carboxylic acids, and enols. TMCS is a silylation catalyst always used with other silylation reagents to increase the reactivity in derivatization of alcohols, alkaloids, amines, biogenic amines, carboxylic acids, phenols, and steroids.

Application

Learn more in the Product Information
Suitable for the derivatization of α-ketoacids, amines, amino acids, cycloserine, histamine and metabolites, phenylethylamines, phosphatidylserines and tryptamines. BSA+TMCS may be used as a derivatizing reagent for the determination of steryl glycosides in biodiesel using gas chromatography–mass spectrometry.
Suitable for the derivatization of a-ketoacids, amines, amino acids, cycloserine, histamine and metabolites, phenylethylamines, phosphatidylserines and tryptamines.

Features and Benefits

  • BSA+TMCS has good solvent properties and can function as a silylation reagent without additional solvents.        
  • Alternatively, the mixture is very soluble in most commonly used silylation solvents.        
  • This combination is extremely sensitive to moisture and should be handled under dry conditions.

Other Notes

Powerful silylation mixture with wide applicability
Reagent for trimethylsilyl diglyceride, trimethylsilyl (TMS) and trimethylsilyl oximes.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1A

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

53.6 °F - closed cup

flash_point_c

12 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCL9037
BCCK4114
BCCK3649
BCCF5339
BCBZ8581

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Terness TA
Environmental Science & Technology, 36 (17), 3855-3863 (2002)
D.L. Sondack et al.
Journal of Pharmacological Sciences, 62, 1344-1344 (1973)
D.R. Knapp
Handbook of Analytical Derivatization Reactions, 202-202 (1979)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
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