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15527

Glycine

Name: Glycine
Brand: SIAL

meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

NH₂CH₂COOH

CAS Number:

56-40-6

Molecular Weight:

75.07

NACRES:

NA.21

PubChem Substance ID:

57647473

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

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Quality Level

200

assay

99-101% (based on anhydrous substance)

form

crystalline powder

quality

meets analytical specification of Ph. Eur., BP, USP

technique(s)

IR spectroscopy: suitable

impurities

hydrolyzable substances, complies, organic volatile impurities, complies (GC), residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤1.0% ninhydrin-positive substances

ign. residue

≤0.1% (as SO₄)

loss

≤0.2% loss on drying, 105 °C, 2 h

color

white

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.)

solubility

H₂O: soluble 25 gm in 100 ml at 25 degrees c, H₂O: soluble 39.1 gm in 100 ml at 50 degrees c, alcohol: soluble 0.06 gm in 100 gm (Absolute), pyridine: soluble 164 parts, alcohol: very slightly soluble, diethyl ether: very slightly soluble

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg

suitability

complies for appearance of solution, complies for reaction against H₂SO₄, in accordance for identity (IR)

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

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Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Amino Acids – Building Blocks of Life Science

Application

Glycine was used for preparing platelets from whole-blood samples and study the stimulation of cytokine expression in leukocytes. It was used for biochemical and tolerance tests.

Biochem/physiol Actions

Glycine has a pivotal role in lowering the plasma lipid levels in diabetic and obese patients by activating the CNS. During brain hypoxia glycine can stabilize the energetics disturbances in brain mitochondria. It also increases the in vitro development of porcine blastocysts when used along with glucose.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Storage Class

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

flash_point_f

No data available

flash_point_c

No data available

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Mechanism underlying the protective effect of glycine in energetic disturbances in brain tissues under hypoxic conditions.

A A Selin et al.

Bulletin of experimental biology and medicine, 153(1), 44-47 (2012-07-19)

Glycine stabilizes energetics of brain mitochondria under conditions of brain hypoxia in vivo modeled by ligation of the common carotid artery in rats. Hypoxia reduced respiratory control in brain cortex mitochondria from 7.7 ± 0.5 to 4.5 ± 0.3. Preliminary

Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content.

F Megraud et al.

Journal of clinical microbiology, 22(6), 1007-1010 (1985-12-01)

"Campylobacter pyloridis" has been recently described as a gastritis-associated bacterium. We studied 20 strains. The bacteria had most of the characteristics of Campylobacter spp. strains. They were hippurate negative and tolerant to triphenyl tetrazolium chloride (at 0.4 and 1 mg/ml).

Glucose and glycine synergistically enhance the in vitro development of porcine blastocysts in a chemically defined medium.

Tomomi Mito et al.

Reproduction, fertility, and development, 24(3), 443-450 (2012-03-10)

In the present study, the effects of glucose and/or glycine on the in vitro development of Day 5 (Day 0=IVF) porcine blastocysts were determined. The addition of 2.5-10 mM glucose to the chemically defined culture medium porcine zygote medium (PZM)-5

Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats.

Jessica T Y Yue et al.

Circulation research, 110(10), 1345-1354 (2012-04-05)

Dysregulation of hepatic triglyceride (TG)-rich very low-density lipoproteins (VLDL-TG) in obesity and type 2 diabetes contributes to the dyslipidemia that leads to cardiovascular morbidity. The central nervous system (CNS), particularly the hypothalamus, regulates hepatic lipid metabolism. Although the underlying neurocircuitry

Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.

F J Neumann et al.

Circulation, 95(10), 2387-2394 (1997-05-20)

Activated platelets tether and activate myeloid leukocytes. To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI. We obtained peripheral

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Global Trade Item Number

SKU	GTIN
15527-1KG-R	04061826750650
15527-2.5KG-R	04061833605455
15527-6X1KG-R	04061833605462
15527-25KG-R	04061833440025
15527-500G-R	04061833440032

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