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Sigma-Aldrich

Silicone oil

high temperature

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Synonym(s):
Poly(dimethylsiloxane-co-methylphenylsiloxane)
Linear Formula:
[Si(CH3)2O]x[Si(CH3)(C6H5)O]y
CAS Number:
63148-52-7
MDL number:
MFCD00133270
PubChem Substance ID:
24850517
NACRES:
NA.21

vapor pressure

<5 mmHg ( 25 °C)

Quality Level

200

parameter

−40-450 °F temp. range (−40-230 °C)

refractive index

n20/D 1.495

density

1.05 g/mL at 25 °C

SMILES string

C[Si](C)=O.C[Si](=O)c1ccccc1

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General description

Silicone oil is a highly viscous oil made up of poly(dimethylsiloxane-co-methylphenylsiloxane) chains.

Application

Silicone oil has been used as a medium component in containerless protein crystallization techniques which do not require contact with a solid surface. It was used as an oil bath during the synthesis of methyl 2-methylazulene-1-carboxylate.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

437.0 °F - closed cup

Flash Point(C)

225.00 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Hui-Ling Cao et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 10), 1901-1910 (2013-10-09)
High-quality crystals are key to obtaining accurate three-dimensional structures of proteins using X-ray diffraction techniques. However, obtaining such protein crystals is often a challenge. Several containerless crystallization techniques have been reported to have the ability to improve crystal quality, but
Colloidal ordering from phase separation in a liquid-crystalline continuous phase.
Loudet J-C, et al.
Nature, 407(6804), 611-613 (2000)
Viscous liquid film flows over a periodic surface.
Trifonov YY.
International Journal of Multiphase Flow, 24(7), 1139-1161 (1999)
Simon J Carter et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(4), 415-426 (2019-08-08)
Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil spin method.Atorvastatin was incubated in fresh rat hepatocytes (0.05-150 nmol/ml) with
Jennifer Li et al.
The European journal of neuroscience, 34(12), 1983-1996 (2011-12-14)
Neuronal activity elicits metabolic and vascular responses, during which oxygen is first consumed and then supplied to the tissue via an increase in cerebral blood flow. Understanding the spatial and temporal dynamics of blood and tissue oxygen (To₂) responses following
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