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17929

O-Methyl-O′-succinylpolyethylene glycol 5′000

Synonym(s):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
31961-02-1
UNSPSC Code:
51171641
NACRES:
NA.26
MDL number:
MFCD00284260
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form

powder

Quality Segment

100, 200

mol wt

Mr ~5100

mp

56-60 °C

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

Application

Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG
Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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