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Merck
CN

18858

5-Aminosalicylic acid

analytical standard

Synonym(s):

5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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About This Item

Linear Formula:
H2NC6H3-2-(OH)CO2H
CAS Number:
89-57-6
Molecular Weight:
153.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329751750
EC Number:
201-919-1
Beilstein/REAXYS Number:
2090421
MDL number:
MFCD00007877

Key Documents

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SMILES string

Nc1ccc(O)c(c1)C(O)=O

InChI key

KBOPZPXVLCULAV-UHFFFAOYSA-N

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

grade

analytical standard

assay

≥98.5% (NT), ≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤0.5% water

mp

275-280 °C (dec.) (lit.)

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)

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Application

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB1643
BCBS1407V

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Rosario Cuomo et al.
United European gastroenterology journal, 2(5), 413-442 (2014-11-02)
The statements produced by the Consensus Conference on Diverticular Disease promoted by GRIMAD (Gruppo Italiano Malattia Diverticolare, Italian Group on Diverticular Diseases) are reported. Topics such as epidemiology, risk factors, diagnosis, medical and surgical treatment of diverticular disease (DD) in
Natalia Pedersen et al.
Inflammatory bowel diseases, 20(12), 2276-2285 (2014-09-24)
To individualize treatment with mesalazine for ulcerative colitis relapses through a self-managed, web-based solution to optimize the short-term disease course. Prospective, open-label, web-guided study with 3 months mesalazine therapy among patients with mild-to-moderate ulcerative colitis. Once a week, patients completed
Alan C Moss et al.
The American journal of gastroenterology, 109(12), 1850-1855 (2014-06-11)
Poor adherence to mesalamine is common and driven by a combination of lifestyle and behavioral factors, as well as health beliefs. We sought to develop a valid tool to identify barriers to patient adherence and predict those at risk for
Grzegorz Garbacz et al.
The Journal of pharmacy and pharmacology, 67(2), 199-208 (2015-01-06)
For the treatment of inflammatory bowel disease, the development of pH responsive modified release dosage forms is one of the most common approaches to achieve targeted drug delivery. In this study, the dissolution behaviour of eight different modified release (MR)
W J Sandborn et al.
Alimentary pharmacology & therapeutics, 41(5), 409-418 (2015-01-16)
Conventional oral corticosteroids are effective at reducing inflammation associated with ulcerative colitis (UC); however, systemic adverse effects limit their use. Budesonide MMX is an extended-release, second-generation corticosteroid that targets delivery of budesonide to the entire colon. To analyse efficacy and
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