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Merck
CN

198218

Patent Blue VF

Dye content 50 %

Synonym(s):

Acid Blue 1, Sulfan Blue

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About This Item

Empirical Formula (Hill Notation):
C27H31N2NaO6S2
CAS Number:
Molecular Weight:
566.66
PubChem Substance ID:
UNSPSC Code:
12171500
Colour Index Number:
42045
NACRES:
NA.47
EC Number:
204-934-1
MDL number:
Technical Service
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form

powder

Quality Level

composition

Dye content, 50%

technique(s)

microbe id | staining: suitable

solubility

H2O: 1 mg/mL

ε (extinction coefficient)

≥50000 at 635-641 nm in H2O, ≥5300 at 408-414 nm in H2O, ≥7500 at 308-314 nm in H2O

λmax

635 nm (2nd), -410 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CCN(CC)c1ccc(cc1)\C(=C2/C=CC(\C=C2)=[N+](\CC)CC)c3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

InChI key

SJEYSFABYSGQBG-UHFFFAOYSA-M

Application

Patent Blue VF has been used:
  • in combination with 99mTc phytate to detect sentinel lymph node (SLN) in early stage cervical cancer patients.
  • to detect heat shock protein (HSP) gp96 induced draining lymph nodes (LNs) in mice.
  • to detect the effect of Asn-Gly-Arg (NGR)-tumor necrosis factor (TNF) on tumor perfusion in murine model.

Biochem/physiol Actions

Patent Blue VF dye is a violet colored powder. It has been used in cosmetic coloring.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-alpha.
Sacchi A
Clinical Cancer Research, 12(1), 175-182 (2006)
P Covarelli et al.
In vivo (Athens, Greece), 26(2), 315-318 (2012-02-22)
The aim of our study was to evaluate feasibility, reliability and cost-benefit balance of sentinel node (SN) biopsies conducted under local anaesthesia (LA) in patients affected by stage I-B or II cutaneous melanoma. A retrospective analysis was carried out in
Effect of Patent Blue V(®) dye on sample interference indices on the Abbott Architect.
Malcolm P McTaggart et al.
Annals of clinical biochemistry, 49(Pt 5), 510-511 (2012-08-24)
David Pavlista et al.
Annals of surgical oncology, 19(11), 3410-3415 (2012-04-25)
This anatomic study details the lymphatic drainage of the upper extremity (UE) and breast, as well as its course in the axilla and its relation to axillary reverse mapping. Two aspects important for breast cancer surgery were followed: connection between
The value of Q-switched Nd:YAG laser after patent blue-enhanced lymphaticovenular anastomosis.
Benoit Ayestaray et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 66(8), 1157-1158 (2013-04-23)

Global Trade Item Number

SKUGTIN
198218-25G04061838762788

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