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Merck
CN

229253

Carminic acid

≥90% (HPLC)

Synonym(s):

Natural Red 4

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About This Item

Empirical Formula (Hill Notation):
C22H20O13
CAS Number:
1260-17-9
Molecular Weight:
492.39
EC Number:
215-023-3
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24853740
MDL number:
MFCD00167028
Colour Index Number:
75470
Beilstein/REAXYS Number:
71651

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Product Name

Carminic acid, ≥90% (HPLC)

InChI key

DGQLVPJVXFOQEV-JNVSTXMASA-N

InChI

1S/C22H20O13/c1-4-8-5(2-6(24)9(4)22(33)34)13(25)10-11(15(8)27)16(28)12(18(30)17(10)29)21-20(32)19(31)14(26)7(3-23)35-21/h2,7,14,19-21,23-24,26,28-32H,3H2,1H3,(H,33,34)/t7-,14-,19+,20-,21+/m1/s1

SMILES string

Cc1c(C(O)=O)c(O)cc2C(=O)c3c(O)c(O)c([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(O)c3C(=O)c12

assay

≥90% (HPLC)

form

powder

optical activity

[α]20/D +3.1°, c = 1 in H2O

color

purple to red-purple
 red to very dark red

mp

136 °C

solubility

1 N acetic acid: 1%, clear to hazy, red

λmax

495 nm

ε (extinction coefficient)

≥13000 at 222-228  nm in ethanol at 0.03 g/L
≥18000 at 275-281 nm in ethanol at 0.03 g/L

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

100

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Application

Carminic acid (CI 75470) is used in Orth′s lithium carmine technique for nuclear staining, Best′s stain for glycogen, and Southgates′s mucicarmine method.

General description

Carmine is a cochineal product usually furnished as an aluminum and calcium salt of carminic acid. Carminic acid is used for human-medical cell diagnosis and serves the purpose of the histological investigation of sample material of human origin. It is suitable for staining nuclei in histological sections. It is utilized in various staining methods including the procedure for detection of glycogen and mucous substances (Best′s carmine), for nuclear staining, or vital staining.

Storage Class

11 - Combustible Solids

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN3703
BCCN0035
BCCL3641
BCCK6261
BCCH4758

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Gabriel J. Lauro, Jack Francis
Natural Food Colorants: Science and Technology (2000)
J.D. Houghton, G.A.F. Hendry
Natural Food Colorants (2012)
Naoki Sugimoto et al.
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 51(1), 19-27 (2010-03-09)
A quantitative NMR (qNMR) method was applied for the determination of carminic acid. Carminic acid is the main component in cochineal dye that is widely used as a natural food colorant. Since several manufacturers only provide reagent-grade carminic acid, there
Xiao Wang et al.
Biomedical materials (Bristol, England), 6(3), 035010-035010 (2011-05-11)
Tendon disorders are common clinical conditions. Tendon tissue engineering provides a new approach for tendon repair by integrating engineered substitutes with their native counterparts. Silk is considered to be a promising candidate for tendon engineering because of its biological and
Gabriela Arroyo-Figueroa et al.
TheScientificWorldJournal, 11, 1005-1016 (2011-05-10)
Trametes versicolor (Tv) fungus can degrade synthetic dyes that contain azo groups, anthraquinone, triphenylmethane polymers, and heterocyclic groups. However, no references have been found related to the degradation of natural dyes, such as the carminic acid that is contained in
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