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31737

Sulfamethoxazole

VETRANAL®, analytical standard

Synonym(s):

4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N1-(5-Methylisoxazol-3-yl)sulfanilamide

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About This Item

Empirical Formula (Hill Notation):
C10H11N3O3S
CAS Number:
723-46-6
Molecular Weight:
253.28
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329753910
EC Number:
211-963-3
Beilstein/REAXYS Number:
6732984
MDL number:
MFCD00010546
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grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1

InChI

1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)

InChI key

JLKIGFTWXXRPMT-UHFFFAOYSA-N

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General description

Sulfamethoxazole is a bacteriostatic antibiotic used in treating coccidiosis, diarrhea and gastroenteritis in humans and is also a known veterinary drug. Sulfamethoxazole in combination with trimethoprim is effective in treating pneumonia. Sulfamethoxazole acts by blocking the folic acid metabolism to produce synergistic antibacterial activity.

Application

Sulfamethoxazole may be used as a reference standard for the determination of the analyte in:
  • Bovine milk by high-performance liquid chromatography method.
  • Pharmaceutical formulations and biological samples by capillary electrophoresis (CE) with end-column electrochemical detection (EC).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9336
BCCJ8018
BCCH5204
BCBW0070
BCBT4571

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Sulfamethoxazole abatement by means of ozonation.
Dantas RF, et al.
Journal of Hazardous Materials, 150(3), 790-794 (2008)
Determination of sulfadiazine and sulfamethoxazole by capillary electrophoresis with end-column electrochemical detection.
You T, et al.
Analyst, 123(11), 2357-2360 (1998)
High-performance liquid chromatography method for the simultaneous determination of sulfamethoxazole and trimethoprim in bovine milk using an on-line clean-up column.
Pereira, AV and Cass, QB
Journal of Chromatography. B, Biomedical Sciences and Applications, 826(1-2), 139-146 (2005)
Ming Xie et al.
Water research, 47(13), 4567-4575 (2013-06-15)
The impact of humic acid fouling on the membrane transport of two pharmaceutically active compounds (PhACs) - namely carbamazepine and sulfamethoxazole - in forward osmosis (FO) was investigated. Deposition of humic acid onto the membrane surface was promoted by the
Jih-Tay Hsu et al.
Journal of hazardous materials, 277, 34-43 (2014-03-19)
Antibiotics are commonly used in swine feed to treat and prevent disease, as well as to promote growth. Antibiotics released into the environment via wastewater could accelerate the emergence of antibiotic-resistant bacteria and resistance genes in the surrounding environment. In
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Global Trade Item Number

SKUGTIN
31737-250MG04061835560219

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