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Merck
CN

32122

5′-Hydroxypiroxicam

VETRANAL®, analytical standard

Synonym(s):

4-Hydroxy-N-(5-hydroxy-2-pyridyl)-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O5S
CAS Number:
77459-78-0
Molecular Weight:
347.35
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754054
MDL number:
MFCD23136990
Beilstein/REAXYS Number:
5142716

Key Documents

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InChI

1S/C15H13N3O5S/c1-18-13(15(21)17-12-7-6-9(19)8-16-12)14(20)10-4-2-3-5-11(10)24(18,22)23/h2-8,19-20H,1H3,(H,16,17,21)

SMILES string

CN1C(C(=O)Nc2ccc(O)cn2)=C(O)c3ccccc3S1(=O)=O

InChI key

CCKOORANQAQKKV-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

General description

5′-Hydroxypiroxicam (CAS:77459-78-0) belongs to the VETRANAL product line of high purity veterinary drug standards used for the determination of the active ingredients of the drug in processed food of animal origin.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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B A Mueller et al.
Pharmacotherapy, 12(2), 93-97 (1992-01-01)
We compared the endoscopic effects and pharmacokinetic profiles of an experimental buccal formulation of piroxicam to oral capsules in an attempt to determine whether nonsteroidal antiinflammatory drug-induced gastropathy is due to a local or systemic effect. Ten healthy subjects received
A C Rudy et al.
British journal of clinical pharmacology, 37(1), 1-5 (1994-01-01)
1. Piroxicam pharmacokinetics were assessed in three groups of subjects: (1) young healthy volunteers, (2) healthy elderly subjects (mean +/- s.d. creatinine clearance 88 +/- 13 ml min-1), and (3) elderly patients with renal insufficiency (creatinine clearance 60 +/- 10
A Avgerinos et al.
Journal of chromatography. B, Biomedical applications, 673(1), 142-146 (1995-11-03)
A simple and rapid (extractionless) high-performance liquid chromatographic method with UV detection, at 330 nm, was developed for the simultaneous determination of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma and urine. Acidified plasma and alkali-treated urine samples are
A Klopas et al.
Journal of pharmaceutical and biomedical analysis, 17(3), 515-524 (1998-07-10)
A zero-crossing first-derivative spectrophotometric method for the determination of piroxicam and its major metabolite 5-hydroxypiroxicam (5-HP) in human plasma is described. This technique permits the quantification of compounds with closely overlapping spectral bands without any separation step. The method consists
High-performance liquid chromatographic analysis of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma and urine.
C J Richardson et al.
Journal of chromatography, 382, 382-388 (1986-10-31)
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