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Merck
CN

32138

Doripenem monohydrate

VETRANAL®, analytical standard

Synonym(s):

(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C15H24N4O6S2 · H2O
CAS Number:
364622-82-2
Molecular Weight:
438.52
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754061
MDL number:
MFCD09749887
Beilstein/REAXYS Number:
15340136

Key Documents

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Product Name

Doripenem monohydrate, VETRANAL®, analytical standard

InChI key

NTUBEBXBDGKBTJ-WGLOMNHJSA-N

SMILES string

[H]O[H].NS(NC[C@H](C1)NC[C@H]1SC2=C(C(O)=O)N3C([C@]([H])([C@H](O)C)[C@@]3([H])[C@H]2C)=O)(=O)=O

InChI

1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7-,8+,9+,10-,11-;/m1./s1

grade

analytical standard

product line

VETRANAL®

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Doripenem monohydrate can be used as the precursor for the preparation of doripenem which may be used as an analytical reference standard for the determination of doripenem in:
  • Bovine muscle by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS).
  • Bulk drug and formulations by high performance thin layer chromatography (HPTLC).
  • Medicinal products by capillary electrophoresis coupled to ultraviolet (UV) detector as well as micellar electrokinetic chromatography (MEKC) with UV detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Doripenem belongs to the carbapenems family of β-lactam antibiotic compounds.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCK7590
BCCF8221
BCBZ8752
BCBR7602V

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Determination of biapenem in a medicinal product by micellar electrokinetic chromatography with sweeping in an enhanced electric field.
Michalska K, et al.
Journal of Chromatography A, 1282(4), 153-160 (2013)
Cynthia L Bristow et al.
Frontiers in pharmacology, 12, 695971-695971 (2021-06-29)
The abundant blood protein α1-proteinase inhibitor (α1PI, Αlpha-1, α1-antitrypsin, SerpinA1) is known to bind to the active site of granule-associated human leukocyte elastase (HLE-G). Less well known is that binding of α1PI to cell surface HLE (HLE-CS) induces lymphocyte locomotion
A validated HPTLC method for the determination of doripenem in pharmaceutical dosage forms.
Kurien J, et al.
International Journal of Pharmaceutical Sciences Review and Research, 27, 317-321 (2014)
Determination of doripenem and related substances in medicinal product using capillary electrophoresis.
Michalska K, et al.
Journal of Separation Science, 34(4), 475-482 (2011)
M Di Rocco et al.
Journal of chromatography. A, 1500, 121-135 (2017-04-30)
A method was developed for the confirmatory and quantitative analysis of 30 β-lactam antibiotic residues in bovine muscle. The method includes 12 penicillins (amoxicillin, ampicillin, cloxacillin, dicloxacillin, mecillinam, methicillin, nafcillin, oxacillin, penicillin G, penicillin V, piperacillin, ticarcillin), 12 cephalosporins (cefacetrile

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