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Merck
CN

32451

2-Hydroxyibuprofen

VETRANAL®, analytical standard

Synonym(s):

2-[4-(2-Hydroxy-2-methylpropyl)phenyl]propionic acid

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About This Item

Empirical Formula (Hill Notation):
C13H18O3
CAS Number:
51146-55-5
Molecular Weight:
222.28
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754218
MDL number:
MFCD08275592
Beilstein/REAXYS Number:
3051852

Key Documents

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InChI

1S/C13H18O3/c1-9(12(14)15)11-6-4-10(5-7-11)8-13(2,3)16/h4-7,9,16H,8H2,1-3H3,(H,14,15)

SMILES string

CC(C(O)=O)c1ccc(CC(C)(C)O)cc1

InChI key

UJHKVYPPCJBOSG-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

Related Categories

General description

2-Hydroxyibuprofen is a well-known human metabolite of ibuprofen. It finds applications as a nonsteroidal and anti-inflammatory drug.

Application

2-Hydroxyibuprofen may be used as a reference standard in the determination of 2-hydroxyibuprofen in urine samples using high-performance liquid chromatography (HPLC) and ultrasound-assisted emulsification microextraction (USAEME) with ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC−MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM7519
BCCH6976
BCCF9004
BCCB9555
BCBZ6938

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Simultaneous quantitative determination of the major phase I and II metabolites of ibuprofen in biological fluids by high-performance liquid chromatography on dynamically modified silica.
Kepp RD, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 696(2), 235-241 (1997)
Wastewater and Public Health: Bacterial and Pharmaceutical Exposures (2015)
Ultrasound-assisted emulsification microextraction combined with ultra-high performance liquid chromatography--tandem mass spectrometry for the analysis of ibuprofen and its metabolites in human urine.
Magiera S and Gulmez S
Journal of Pharmaceutical and Biomedical Analysis, 92(2), 193-202 (2014)
Emilia Waraksa et al.
Journal of separation science, 41(20), 3881-3891 (2018-08-14)
Ibuprofen is widely used in human and veterinary medicine for the treatment of chronic pain as well as rheumatic and musculoskeletal disorders. However, the analgesic and anti-inflammatory properties of Ibuprofen have contributed to frequent drug abuse in equestrian sports. A

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