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32476

Selamectin

VETRANAL®, analytical standard

Synonym(s):

(5Z)-25-Cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a

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About This Item

Empirical Formula (Hill Notation):
C43H63NO11
CAS Number:
220119-17-5
Molecular Weight:
769.96
MDL number:
MFCD31621085
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O/N=C1[C@]2([H])[C@]3(O)[C@@](C(O[C@@H]4C[C@]5(O[C@@](C/C=C(C)/[C@@H](O[C@]6([H])C[C@@H]([C@@H](O)[C@H](C)O6)OC)[C@@H](C)/C=C/C=C3\CO2)([H])C4)O[C@H](C7CCCCC7)[C@@H](C)CC5)=O)([H])C=C\1C

InChI

1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1

InChI key

AFJYYKSVHJGXSN-XHKIUTQPSA-N

General description

Selamectin (25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide) is a novel endectocide. It is an anti-parasitic agent and has a unique combination of safety and efficacy both in cats and dogs following both topical and oral administration. It prevents ticks and fleas, immature heartworms, ascarids and intestinal hookworms. It can be easily tolerated even at higher dosages than 22,23-dihydroavermectin B1a (DHAVM).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6326
BCCH7180
BCCC4528
BCBZ9986
BCBZ4029

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Chandan Seth et al.
PloS one, 11(12), e0168170-e0168170 (2016-12-16)
The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for
Selamectin: a novel broad-spectrum endectocide for dogs and cats
Bishop, B. F., et al.
Veterinary Parasitology, 91 (3), 163-176 (2000)
Alice Melotti et al.
EMBO molecular medicine, 6(10), 1263-1278 (2014-08-22)
Constitutive activation of canonical WNT-TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT-TCF antagonists in clinical use. We have performed a repositioning screen for WNT-TCF response blockers aiming to recapitulate the genetic
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Global Trade Item Number

SKUGTIN
32476-10MG04061826711736