32496
1-Hydroxyibuprofen
VETRANAL®, analytical standard
Synonym(s):
2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propionic acid
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About This Item
Empirical Formula (Hill Notation):
C13H18O3
CAS Number:
Molecular Weight:
222.28
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
22307543
InChI key
RMOQYHYFRKTDRI-UHFFFAOYSA-N
SMILES string
CC(C)C(O)c1ccc(cc1)C(C)C(O)=O
InChI
1S/C13H18O3/c1-8(2)12(14)11-6-4-10(5-7-11)9(3)13(15)16/h4-9,12,14H,1-3H3,(H,15,16)
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Related Categories
General description
1-Hydroxyibuprofen is one of the metabolites of ibuprofen, which is classified under the non-steroidal anti-inflammatory drugs (NSAIDs) group of compounds.
Application
1-Hydroxyibuprofen has been used as an analytical reference standard for the determination of the analyte in:
It may be used as an analytical reference standard for the determination of the analyte in:
- Sewage sludge samples by QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction with on-line solid-phase extract purification and pre-concentration, followed by analysis using liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) operating in multiple reaction monitoring (MRM) mode of detection.
It may be used as an analytical reference standard for the determination of the analyte in:
- Human urine samples by ultrasound-assisted emulsification microextraction (USAEME) and ultra-high performance liquid chromatography (UHPLC) with (ESI-MS/MS) with (MRM) detection.
- Wastewater samples by hollow fiber liquid phase microextraction (HF-LPME) followed by LC-ESI-MS/MS.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Behaviour of nonsteroidal anti-inflammatory drugs and eight of their metabolites during wastewater treatment studied by hollow fibre liquid phase microextraction and liquid chromatography mass spectrometry.
Larsson E, et al.
The Science of the Total Environment, 485, 300-308 (2014)
Ultrasound-assisted emulsification microextraction combined with ultra-high performance liquid chromatography-tandem mass spectrometry for the analysis of ibuprofen and its metabolites in human urine.
Magiera S and Gulmez S
Journal of Pharmaceutical and Biomedical Analysis, 92, 193-202 (2014)
Innovative combination of QuEChERS extraction with on-line solid-phase extract purification and pre-concentration, followed by liquid chromatography-tandem mass spectrometry for the determination of non-steroidal anti-inflammatory drugs and their metabolites in sewage sludge.
Rossini D, et al.
Analytica Chimica Acta, 935, 269-281 (2016)
Aleksandar Lolić et al.
The Science of the total environment, 508, 240-250 (2014-12-08)
The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial
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