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Merck
CN

32802

Triclabendazole

VETRANAL®, analytical standard

Synonym(s):

5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole

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About This Item

Empirical Formula (Hill Notation):
C14H9Cl3N2OS
CAS Number:
68786-66-3
Molecular Weight:
359.66
NACRES:
NA.24
PubChem Substance ID:
329754333
UNSPSC Code:
41116107
MDL number:
MFCD00864519

Key Documents

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InChI key

NQPDXQQQCQDHHW-UHFFFAOYSA-N

SMILES string

CSc1nc2cc(Cl)c(Oc3cccc(Cl)c3Cl)cc2[nH]1

InChI

1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

Quality Level

100

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General description

Chemical structure: benzimidazole

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH3573
BCCC1583
BCBS2918V

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Apparent triclabendazole-resistant human Fasciola hepatica infection, the Netherlands.
Annemarie J S Winkelhagen et al.
Emerging infectious diseases, 18(6), 1028-1029 (2012-05-23)
Michelle Whelan et al.
Journal of chromatography. A, 1275, 41-47 (2013-01-08)
Triclabendazole is the only anthelmintic drug, which is active against immature, mature and adult stages of fluke. The objective of this work was to develop an analytical method to quantify and confirm the presence of triclabendazole residues around the MRL.
Fidel Villegas et al.
PLoS neglected tropical diseases, 6(8), e1720-e1720 (2012-08-11)
The Bolivian northern Altiplano is characterized by a high prevalence of Fasciola hepatica infection. In order to assess the feasibility, safety and efficacy of large-scale administration of triclabendazole as an appropriate public health measure to control morbidity associated with fascioliasis
R Daniel et al.
The Veterinary record, 171(6), 153-153 (2012-07-14)
A faecal egg count reduction test, using composite samples, was developed in order to assess the efficacy of the flukicide, triclabendazole (TCBZ) on commercial sheep farms in England and Wales. First, a comparison between individual counts and composite counts was
Rodrigo Sanabria et al.
Veterinary parasitology, 193(1-3), 105-110 (2013-01-01)
The experiments described here were designed to characterize the status of susceptibility/resistance to albendazole (ABZ) and triclabendazole (TCBZ) of a Fasciola hepatica isolate (named CEDIVE isolate) recovered from infected sheep (Gualeguay, Argentina) and maintained under laboratory conditions. Two separate clinical
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