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Merck
CN

32936

Fumonisin B1

reference material, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonym(s):

Fumonisin B1 from Fusarium moniliforme, Macrofusine

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About This Item

Empirical Formula (Hill Notation):
C34H59NO15
CAS Number:
Molecular Weight:
721.83
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
MDL number:
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Product Name

Fumonisin B1, reference material, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

InChI

1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1

SMILES string

CCCC[C@@H](C)[C@@H](OC(=O)C[C@@H](CC(O)=O)C(O)=O)[C@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@H](C)N)OC(=O)C[C@@H](CC(O)=O)C(O)=O

InChI key

UVBUBMSSQKOIBE-DSLOAKGESA-N

grade

analytical standard
reference material

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

−20°C

Quality Level

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Analysis Note

purity : ≥92.5% (HPLC)

Application

Fumonisin B1 may be used as an analytical reference standard for the determination of the analyte in:
  • Swine liver by high performance liquid chromatography-fluorescence detection (HPLC-FLD).
  • Cereals by HPLC.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Fungal metabolite believed to cause leukoencephalomalacia in horses.

General description

Fumonisins are a family of mycotoxins that are characterized by their structurally related homologs. They are generally produced by fungi of Fusarium species.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Kidney,Liver

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

高风险级别生物产品--毒素类产品
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Influence of experimental parameters on the fluorescence response and recovery of the high-performance liquid chromatography analysis of fumonisin B1.
Samapundo S, et al.
Journal of Chromatography A, 1109(2), 312-316 (2006)
Simple method for the simultaneous isolation and determination of fumonisin B1 and its metabolite aminopentol-1 in swine liver by liquid chromatography-fluorescence detection.
Pagliuca G, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 819(1), 97-103 (2005)
K Bordin et al.
Food chemistry, 155, 174-178 (2014-03-07)
In this study, fumonisin B1 (FB1) consumption was assessed through determination of FB1 in corn meal, corn flour, corn flakes, polenta, canned corn and popcorn collected from homes of residents of Pirassununga, São Paulo, Brazil, and using a Food Frequency
Ronald T Riley et al.
Molecular nutrition & food research, 56(9), 1445-1455 (2012-07-21)
Fumonisins (FB) are mycotoxins found in maize. The purpose of this study was to (i) determine the relationship between FB(1) , FB(2) , and FB(3) intake and urinary excretion in humans, (ii) validate a method to isolate urinary FB on
Anil A Chuturgoon et al.
Toxicology letters, 227(1), 50-55 (2014-03-13)
Fumonisin B₁ (FB₁), a common mycotoxin contaminant of maize, is known to inhibit sphingolipid biosynthesis and has been implicated in hepatocellular carcinoma promoting activity in humans and animals. MicroRNAs (miRNA) are small noncoding RNAs that regulate gene expression via translational

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