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Merck
CN

33420

1-Naphthol

≥99% (GC), puriss. p.a., reag. Ph. Eur.

Synonym(s):

α-Naphthol, 1-Hydroxynaphthalene

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About This Item

Linear Formula:
C10H7OH
CAS Number:
Molecular Weight:
144.17
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
201-969-4
MDL number:
Beilstein/REAXYS Number:
1817321
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Product Name

1-Naphthol, puriss. p.a., reag. Ph. Eur., ≥99% (GC)

InChI key

KJCVRFUGPWSIIH-UHFFFAOYSA-N

InChI

1S/C10H8O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11H

SMILES string

Oc1cccc2ccccc12

agency

USP/NF
reag. Ph. Eur.

vapor density

4.5 (120 °C, vs air)

vapor pressure

1 mmHg ( 94 °C)

grade

puriss. p.a.

assay

≥99% (GC)

autoignition temp.

1007 °F

expl. lim.

5 %

impurities

≤0.001% heavy metals (as Pb)
≤0.2% naphthaline (GC)
≤0.2% water (Karl Fischer)
≤0.5% 2-naphthol (GC)

ign. residue

≤0.05% (as SO4)

bp

278-280 °C (lit.)

mp

94-96 °C (lit.)
94-97 °C

anion traces

chloride (Cl-): ≤50 mg/kg

cation traces

Fe: ≤10 mg/kg

Quality Level

Gene Information

human ... CYP1A2(1544)

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Packaging

bottled under inert gas

Application


  • A ′conovenomic′ analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.: This research underscores the critical role of post-translational modifications in the biological activity of peptides derived from cone snail venom, illustrating the potential for developing novel pharmacological agents using peptide synthesis techniques like those involving Fmoc-Asp(OtBu)-OH (Bergeron et al., 2013).

  • Parallel high-throughput accurate mass measurement using a nine-channel multiplexed electrospray liquid chromatography ultraviolet time-of-flight mass spectrometry system.: This paper discusses a breakthrough in mass spectrometry, highlighting a method for high-throughput analysis which could be critical for the characterization of complex peptide products synthesized using Fmoc-Asp(OtBu)-OH (Fang et al., 2003).


signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1A - STOT SE 2 Oral - STOT SE 3

target_organs

Kidney, Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

257.0 °F - closed cup

flash_point_c

125 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Accurate hydrogen-bonding energies between 1-naphthol and water, methanol and ammonia.
Burgi T, et al
Chemical Physics Letters, 246(3), 291-299 (1995)
Characterization of duloxetine HCL API and its process related impurities
Karagiannidou E, et al.
International Journal of Analytical, Pharmaceutical and Biomedical Sciences, 3(2) (2014)
Baoliang Chen et al.
Chemosphere, 76(1), 127-133 (2009-03-14)
Biochars, derived from biomass, are increasingly recognized as an environmental-friendly sorbent to abate organic pollutants. Sorption variations of biochars with their pyrolytic temperatures are evaluated. Nine biochars of orange peels with different pyrolytic temperatures (150-700 degrees C, referred as OP150-OP700)
Anika Kasprick et al.
European journal of immunology, 45(5), 1462-1470 (2015-02-14)
The role of mast cells (MCs) in autoimmunity is the matter of an intensive scientific debate. Based on observations in different MC-deficient mouse strains, MCs are considered as fundamental players in autoimmune diseases. However, most recent data suggest that the
Hongbo Zhang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(8), 1286-1293 (2012-01-24)
In vitro glucuronidation assays of diclofenac and indomethacin at pH 7.4 are biased by the instability of the glucuronides due to acyl migration. The extent of this acyl migration may be reduced significantly by performing the glucuronidation reaction at pH

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