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Merck
CN

33428

4,4′-MDI

analytical standard

Synonym(s):

4,4′-Methylenebis(phenyl isocyanate), 4,4′-Diphenylmethane diisocyanate, 4,4′-Methylenediphenyl diisocyanate, 4,4′-MDI, Bis(4-isocyanatophenyl)methane

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About This Item

Linear Formula:
CH2(C6H4NCO)2
CAS Number:
101-68-8
Molecular Weight:
250.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754540
EC Number:
202-966-0
Beilstein/REAXYS Number:
797662
MDL number:
MFCD00036131

Key Documents

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Product Name

4,4′-MDI, analytical standard

SMILES string

O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1

InChI key

UPMLOUAZCHDJJD-UHFFFAOYSA-N

InChI

1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2

grade

analytical standard

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

200 °C/5 mmHg (lit.)

mp

42-45 °C (lit.)

density

1.18 g/mL at 25 °C (lit.)

application(s)

environmental

format

neat

storage temp.

−20°C

Quality Level

100

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Application

4,4′-MDI may be used as an analytical standard for the determination of the analyte in wastewater and air samples, and human biological samples by various chromatographic techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

4,4′-MDI can be extensively used to make urethane elastomers and urethane coatings.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

411.8 °F - closed cup

flash_point_c

211 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6182
BCCM3996
BCCF3263
BCBT8693

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Hatada
Macromolecular Design of Polymeric Materials, 40 (1997)
A highly sensitive high-performance liquid chromatographic procedure for the determination of isocyanates in air
Schmidtke F and Seifert B
Fresenius Journal of Analytical Chemistry, 336(8), 647-654 (1990)
Yan Zhu et al.
Journal of chromatography. A, 956(1-2), 215-220 (2002-07-11)
A method has been developed for the simultaneous determination of a range of aromatic amines using cation-exchange chromatography performed on a standard ion chromatography column using d.c. amperometric detection. The analytes separated were 2,4- and 2,6-toluenediamine (2,4- and 2,6-TDA), aniline
Sensitive determination of airborne diisocyanates by HPLC: 4, 4?-Diphenylmethane-diisocyanate (MDI)
Schulz M and Salthammer T
Fresenius Journal of Analytical Chemistry, 362(3), 289-293 (1998)
Liquid chromatography and mass spectrometry determination of aromatic amines in hydrolysed urine from workers exposed to thermal degradation products of polyurethane
Skarping G, et al.
Chromatographia, 39(9-10), 619-623 (1994)
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