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33864

Tilmicosin

VETRANAL®, analytical standard, mix of isomers

Synonym(s):

20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin

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About This Item

Empirical Formula (Hill Notation):
C46H80N2O13
Molecular Weight:
869.13
NACRES:
NA.24
PubChem Substance ID:
329754677
UNSPSC Code:
41116107
MDL number:
MFCD19705582
Technical Service
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grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC1OC(OCC(C(CC)O2)/C=C(/C=C/C(C(C)CC(CCN3CC(C)CC(C)C3)C(OC4OC(C)C(O)C(N(C)C)C4O)C(C)C(O)CC2=O)=O)C)C(OC)C(OC)C1O

InChI

1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1

InChI key

JTSDBFGMPLKDCD-XVFHVFLVSA-N

General description

Tilmicosin is a semisynthetic macrolide antibiotic, with broad spectrum activity towards Mycoplasma spp., Pasteurella spp., and various gram-positive organisms in animals.

Application

Tilmicosin may be used as a reference standard for the determination of the analyte in chicken, swine, cattle, sheep tissues and milk samples using liquid chromatography with ultraviolet detection (LC-UV).
Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

target_organs

Cardio-vascular system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6594
BCCM4665
BCCG2736
BCCD7299
BCCB4507

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Yingyu Liu et al.
Microbial drug resistance (Larchmont, N.Y.), 18(6), 604-615 (2012-09-01)
The Haemophilus parasuis respiratory tract pathogen poses a severe threat to the swine industry despite available antimicrobial therapies. To gain a more detailed understanding of the molecular mechanisms underlying H. parasuis response to tilmicosin treatment, microarray technology was applied to
Jacob Poehlsgaard et al.
ACS chemical biology, 7(8), 1351-1355 (2012-05-09)
The veterinary antibiotic tildipirosin (20,23-dipiperidinyl-mycaminosyl-tylonolide, Zuprevo) was developed recently to treat bovine and swine respiratory tract infections caused by bacterial pathogens such as Pasteurella multocida. Tildipirosin is a derivative of the naturally occurring compound tylosin. Here, we define drug-target interactions
Niels Møller Andersen et al.
Antimicrobial agents and chemotherapy, 56(11), 6033-6036 (2012-08-29)
Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50%
View All Related Papers

Global Trade Item Number

SKUGTIN
33864-100MG-R04061826745007