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Merck
CN

33987

Olaquindox

VETRANAL®, analytical standard

Synonym(s):

N-(2-Hydroxyethyl)-3-methyl-2-quinoxalinecarboxamide 1,4-dioxide

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About This Item

Empirical Formula (Hill Notation):
C12H13N3O4
CAS Number:
23696-28-8
Molecular Weight:
263.25
NACRES:
NA.24
PubChem Substance ID:
329754726
UNSPSC Code:
41116107
EC Number:
245-832-7
MDL number:
MFCD00210341

Key Documents

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Product Name

Olaquindox, VETRANAL®, analytical standard

InChI key

TURHTASYUMWZCC-UHFFFAOYSA-N

InChI

1S/C12H13N3O4/c1-8-11(12(17)13-6-7-16)15(19)10-5-3-2-4-9(10)14(8)18/h2-5,16H,6-7H2,1H3,(H,13,17)

SMILES string

Cc1c(C(=O)NCCO)[n+]([O-])c2ccccc2[n+]1[O-]

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

Olaquindox may be used as a reference standard in the determination of olaquindox in feed samples using matrix solid-phase dispersion extraction (MSPDE) and hydrophilic interaction ultra-high-pressure liquid chromatography (HILIC-UHPLC) with photodiode array detector.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Olaquindox is an antibiotic veterinary drug, used as a growth promoter for pig farming.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H334

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1618
BCBW1743

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Zhixiang Xu et al.
Journal of the science of food and agriculture, 92(13), 2696-2702 (2012-04-17)
Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Due to health concerns over possible carcinogenic, mutagenic and photoallergenic effects of olaquindox on animals, the development of simple, rapid and sensitive
Lei Zhang et al.
Journal of hazardous materials, 197, 389-396 (2011-10-25)
Multi-walled carbon nanotubes (MWCNT) were employed for the sorption of olaquindox (OLA) from aqueous solution. A detailed study of the adsorption process was performed by varying pH, ionic strength, sorbent amount, sorption time and temperature. The adsorption mechanism is probably
Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli
Hansen HL, et al.
Antimicrobial Agents and Chemotherapy, 48(9), 3332-3337 (2004)
Jiajie Zou et al.
Mutation research, 676(1-2), 27-33 (2009-06-03)
Olaquindox, a synthetic antimicrobial compound, is widely used in China as feed additive for growth promotion. However, it is a mutagen with its functional mechanism yet to be unclear. The purpose of this study was to investigate the genotoxic effects
Zhao-Ying Liu et al.
Toxicology letters, 195(1), 51-59 (2010-03-12)
Olaquindox, N-(2-hydroxyethyl)-3-methyl-2-quinoxalinecarboxamide-1,4-di-N-oxide, is one of the quinoxaline-dioxides used widely as an antimicrobial growth promoter in pig production. Its toxicities were reported to be closely related to the formation of N-oxide reductive metabolites. The present study presents the metabolism and N-oxide
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