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Merck
CN

33998

Melengestrol acetate

VETRANAL®, analytical standard

Synonym(s):

17α-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione, MGA

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About This Item

Empirical Formula (Hill Notation):
C25H32O4
CAS Number:
2919-66-6
Molecular Weight:
396.52
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754737
EC Number:
220-859-7
Beilstein/REAXYS Number:
2066919
MDL number:
MFCD00072142

Key Documents

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Product Name

Melengestrol acetate, VETRANAL®, analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

InChI

1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1

InChI key

UDKABVSQKJNZBH-DWNQPYOZSA-N

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC(=C)[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

mp

202-204 °C (lit.)

application(s)

clinical testing

format

neat

Quality Level

100

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Application

Melengestrol acetate may be used as a reference standard for the determination of the analyte in:
  • Milk using turborFlow online solid phase extraction (SPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Kidney fats by ultra-performance convergence chromatography-tandem mass spectrometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Melengestrol acetate belongs to the family of hormones. This acetylgestagen compound is known to elicit a gestagenic effect in vivo.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6868
BCBT4125

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Simultaneous determination of seven gestagens in kidney fats by Ultra Performance Convergence Chromatography tandem mass spectrometry.
Tao Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 988, 143-148 (2015)
Rapid determination of 88 veterinary drug residues in milk using automated TurborFlow online clean-up mode coupled to liquid chromatography-tandem mass spectrometry.
Zhu WX, et al.
Talanta, 148, 401- 411 (2016)
D J Patterson et al.
Journal of animal science, 67(8), 1895-1906 (1989-08-01)
Expanded use of artificial insemination in the beef cattle industry depends on successful application of treatments designed to synchronize estrus. Regulation of estrous cycles is associated with control of the corpus luteum (CL), whose life span and secretory activity are
D McAloose et al.
Veterinary pathology, 44(3), 320-326 (2007-05-11)
Melengestrol acetate (MGA), a potent synthetic progestin, has been used as a contraceptive in zoo felids since 1975. Mammary gland carcinomas have been linked to MGA treatment in zoo felids, but the histologic features of these tumors and steroid receptor
D R Eborn et al.
Journal of animal science, 91(2), 666-672 (2012-12-12)
Two experiments were conducted over 3 yr to determine pregnancy rates in beef heifers after a timed AI in response to the 7-11 Synch protocol. In Exp. 1, 179 heifers were either fed melengestrol acetate (MGA; 7-11 Synch) or given
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