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Merck
CN

34078

Oxyclozanide

VETRANAL®, analytical standard

Synonym(s):

2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide, 3,3′,5,5′,6-Pentachloro-2′-hydroxysalicylanilide

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About This Item

Empirical Formula (Hill Notation):
C13H6Cl5NO3
CAS Number:
2277-92-1
Molecular Weight:
401.46
NACRES:
NA.24
PubChem Substance ID:
329754798
UNSPSC Code:
41116107
EC Number:
218-904-0
MDL number:
MFCD00864507

Key Documents

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InChI key

JYWIYHUXVMAGLG-UHFFFAOYSA-N

InChI

1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)

SMILES string

Oc1c(Cl)cc(Cl)cc1NC(=O)c2c(O)c(Cl)cc(Cl)c2Cl

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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General description

Oxyclozanide is an anthelmintic agent, which can show activity against Fasciola hepatica, a parasitic trematode and hence, can be used in the treatment of liver fluke infections.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5895
BCCK0517
BCCJ3689
BCCD2132
BCCC1795

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Per Björk et al.
PloS one, 8(5), e63012-e63012 (2013-05-15)
S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation
J Mabus et al.
Journal of helminthology, 62(2), 127-132 (1988-06-01)
Laboratory hamsters (Mesocricetus auratus) were infected with Echinostoma revolutum (Trematoda). Immunoelectrophoretic studies of hamster serum showed no demonstrable antibody response to E. revolutum. Histopathologic examination of intestinal tissue of infected hamsters showed erosion of intestinal villi and lymphocytic infiltration as
B O Fagbemi et al.
Veterinary parasitology, 69(3-4), 231-240 (1997-05-01)
Antigens that were specific to Fasciola gigantica were obtained from the whole worm homogenate of the parasite by immunoaffinity chromatography in cyanogen bromide-activated sepharose 4B columns and used for the production of monoclonal antibodies. The F. gigantica-specific monoclonal antibody was
I Bremner et al.
The Veterinary record, 123(9), 217-218 (1988-08-27)
The benefits of the inclusion of cobalt and selenium supplements in anthelmintic preparations were demonstrated in a 10 week trial with cobalt- and selenium-deficient blackface wethers. The anthelmintics were based on oxfendazole and on levamisole plus oxyclozanide; three doses provided
N A Mohammed-Ali et al.
Journal of veterinary pharmacology and therapeutics, 10(2), 127-133 (1987-06-01)
The pharmacokinetics of oxyclosanide, rafoxanide and closantel were investigated in sheep (n = 5). All three drugs were extensively (greater than 99%) bound to plasma proteins and the plasma concentration/time curve was best described by a tri-exponential equation. Closantel and
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