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Merck
CN

34088

Nitroxinil

VETRANAL®, analytical standard

Synonym(s):

4-Hydroxy-3-iodo-5-nitrobenzonitrile, Nitroxynil

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About This Item

Empirical Formula (Hill Notation):
C7H3IN2O3
CAS Number:
1689-89-0
Molecular Weight:
290.01
NACRES:
NA.24
PubChem Substance ID:
329754805
UNSPSC Code:
41116107
EC Number:
216-884-8
MDL number:
MFCD00070776

Key Documents

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Product Name

Nitroxinil, VETRANAL®, analytical standard

InChI key

SGKGVABHDAQAJO-UHFFFAOYSA-N

InChI

1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H

SMILES string

Oc1c(I)cc(cc1[N+]([O-])=O)C#N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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Application

Nitroxinil may be used as a reference standard in the determination of nitroxinil in veterinary active pharmaceutical ingredient manufacturing and bovine kidney using reversed-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Nitroxinil is an anthelmintic agent, which is also an antiparasite. It is highly effective against Fasciola species and its mode of action involves uncoupling the oxidative phosphorylation in liver flukes and also reduces spermatogenesis in surviving flukes, resulting in fewer fertile eggs.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM3495
BCCD2539
BCCB1548

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M Alvinerie et al.
Journal of veterinary pharmacology and therapeutics, 14(2), 170-173 (1991-06-01)
The binding of nitroxynil to total plasma proteins of cows, sheep and rabbits was characterized using equilibrium dialysis. The data indicate clearly that nitroxynil was highly (97-98%) bound to plasma protein of each animal. This linear binding would be due
W J Blanchflower et al.
The Analyst, 114(9), 1013-1015 (1989-09-01)
A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction step. Any nitroxynil present was separated from interfering compounds by high-performance
G Baziard-Mouysset et al.
Annales pharmaceutiques francaises, 54(5), 223-227 (1996-01-01)
Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl
L Moreno et al.
Research in veterinary science, 88(2), 315-320 (2009-11-07)
The effect of age/body weight in the plasma disposition kinetics of ivermectin (IVM) and nitroxynil (NTX) after their co-administration as a combined formulation to sheep was studied. Sixteen (16) male sheep were allocated into two experimental groups (n=8 each): (a)
Efficacy of nitroxynil against ivermectin, benzimidazole and salicylanilide resistant H contortus.
P C Jeannin et al.
The Veterinary record, 126(25), 624-625 (1990-06-23)
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