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34091

Flubendazol

VETRANAL®, analytical standard

Synonym(s):

Flumoxanal, Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate

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About This Item

Empirical Formula (Hill Notation):
C16H12FN3O3
CAS Number:
31430-15-6
Molecular Weight:
313.28
NACRES:
NA.24
PubChem Substance ID:
329754807
UNSPSC Code:
41116107
EC Number:
250-624-4
MDL number:
MFCD00871999
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Quality Level

100

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccc(F)cc3

InChI

1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

InChI key

CPEUVMUXAHMANV-UHFFFAOYSA-N

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General description

Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol is an injectable benzimidazole drug; though it is poorly absorbed it is quite effective in the treatment of trycocephalus, ascaris and oxyuriasis in both children and adults.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
VETRANAL® analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN0021
BCCM4882
BCCD3951
BCBW0774

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Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability
Moreno.L, et al.
Journal of Veterinary Pharmacology and Therapeutics, 27, 299-308 (2004)
Achiral and chiral high-performance liquid chromatographic determination of flubendazole and its metabolites in biomatrices using UV photodiode-array and mass spectrometric detection
Nobilis M, et al.
Journal of Chromatography A, 1149, 112-120 (2007)
Laura Ceballos et al.
Chemotherapy, 56(5), 386-392 (2010-10-16)
Cystic echinococcosis (CE) is an important public health problem worldwide. Flubendazole, administered in tablets, has shown poor in vivo efficacy against CE in humans. However, flubendazole prepared as a solution caused a marked reduction in hydatid cysts developed in mice.
S Squires et al.
Veterinary parasitology, 185(2-4), 352-354 (2011-10-26)
The efficacy of a commercially available flubendazole-based product and a commercially available herbal product were compared against three species of helminth parasites of chickens: Ascaridia galli, Heterakis gallinarum and Capillaria spp. A total of 48 naturally infected chickens were used
Hana Bártíková et al.
Parasitology, 139(6), 809-818 (2012-02-09)
The drug-metabolizing enzymes of some helminths can deactivate anthelmintics and therefore partially protect helminths against these drugs' toxic effect. The aim of our study was to assess the activity of the main drug-metabolizing enzymes and evaluate the metabolism of selected
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Global Trade Item Number

SKUGTIN
34091-100MG04061826753439

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