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Merck
CN

34093

Closantel

PESTANAL®, analytical standard

Synonym(s):

5′-Chloro-4′-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2′-methylsalicylanilide, N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

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About This Item

Empirical Formula (Hill Notation):
C22H14Cl2I2N2O2
CAS Number:
57808-65-8
Molecular Weight:
663.07
NACRES:
NA.24
PubChem Substance ID:
329754809
UNSPSC Code:
41116107
EC Number:
260-967-1
MDL number:
MFCD00661151

Key Documents

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InChI key

JMPFSEBWVLAJKM-UHFFFAOYSA-N

InChI

1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)

SMILES string

Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c3cc(I)cc(I)c3O

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

storage temp.

2-8°C

Quality Level

100

Related Categories

General description

Closantel belongs to the salicylanilide class of anthelmintics, that can extensively bind to the plasma albumin. It can be effectively used against, a vast range of blood feeding internal parasites.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ5430
BCBZ7571
BCBT3303

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Aldo Segura-Cabrera et al.
Journal of computer-aided molecular design, 25(12), 1107-1119 (2011-11-22)
Onchocerciasis is a leading cause of blindness with at least 37 million people infected and more than 120 million people at risk of contracting the disease; most (99%) of this population, threatened by infection, live in Africa. The drug of
F R Bakunzi
Journal of the South African Veterinary Association, 79(1), 54-55 (2008-08-06)
A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed sheep in a semi-arid area near Mafikeng, South Africa, from January to March 2006. In the herds belonging to twelve smallholder sheep farmers, the efficacies
The effect of a parenteral ivermectin/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle
Hanna.B.E.R, et al.
Veterinary Parasitology, 142, 78-90 (2006)
Han-Wen Sun et al.
Journal of chromatographic science, 46(4), 351-355 (2008-04-12)
A liquid chromatographic method for the determination of closantel residues in milk and tissues is developed and validated. An acetonitrile-acetone solution (80:20, v/v) is used for the extraction of closantel residues from milk and animal tissues, and the extract is
J J van der Lugt et al.
Journal of comparative pathology, 136(2-3), 87-95 (2007-02-03)
Toxicity of closantel, a halogenated salicylanilide anthelmintic, is described in 11 sheep and a goat, humanely killed 4-70 days after accidental overdosage. Status spongiosis of the cerebrum and cerebellum was present, its severity decreasing with time after treatment. Ultrastructurally, vacuoles
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