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Merck
CN

35485

2,4′-DDD

PESTANAL®, analytical standard

Synonym(s):

1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, (2,4′-Dichlorodiphenyl)dichloroethane, o,p′-DDD, Mitotane

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About This Item

Linear Formula:
(ClC6H4)2CHCHCl2
CAS Number:
53-19-0
Molecular Weight:
320.04
PubChem Substance ID:
329755170
UNSPSC Code:
41116107
MDL number:
MFCD00000850
NACRES:
NA.24
EC Number:
200-166-6
Beilstein/REAXYS Number:
2056007

Key Documents

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InChI key

JWBOIMRXGHLCPP-UHFFFAOYSA-N

InChI

1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H

SMILES string

ClC(Cl)C(c1ccc(Cl)cc1)c2ccccc2Cl

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

Quality Level

100

Gene Information

human ... CYP11A1(1583), CYP11B1(1584)

Related Categories

General description

2,4′-DDD is generally used to reduce the endogenous CORT neuropeptide, which might mask the total population of intracellular corticosteroid receptors in sparrows. It is an adrenal specific agent, which can find potent applications in the treatment of adrenocortical carcinoma (ACC).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN1763
BCCF3012
BCBS6884
BCBS6884V

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Mitotane for adrenocortical carcinoma treatment
SH and MF
Current Opinion in Investigational Drugs, 6(4), 386-394 (2005)
Pharmacological characterization of intracellular, membrane, and plasma binding sites for corticosterone in house sparrows
Breuner.WC and Orchinik M
General and Comparative Endocrinology, 163(1), 214-224 (2009)
Optimal treatment of adrenocortical carcinoma with mitotane: results in a consecutive series of 96 patients
Haak.R.H, et al.
British Journal of Cancer, 69(5), 947-951 (1994)
A Redlich et al.
Klinische Padiatrie, 224(6), 366-371 (2012-11-13)
Adrenocortical cancer (ACC) in childhood is a rare disease with poor prognosis. Complete surgical resection, systemic chemotherapy, and mitotane therapy are important curative treatment options for patients with advanced-stage tumors. Since 1997, pediatric ACC patients in Germany have been treated
Lawrence S Kirschner
Trends in endocrinology and metabolism: TEM, 23(7), 343-350 (2012-05-26)
Adrenocortical carcinoma (ACC) is a rare cancer for which few treatment options have been available. Currently, the best available treatment involves combination chemotherapy with the adrenolytic drug mitotane, although the response rate remains modest. Over the past 10 years there
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