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Merck
CN

36127

Climbazole

PESTANAL®, analytical standard

Synonym(s):

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

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About This Item

Empirical Formula (Hill Notation):
C15H17ClN2O2
CAS Number:
38083-17-9
Molecular Weight:
292.76
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329755277
EC Number:
253-775-4
Beilstein/REAXYS Number:
618020
MDL number:
MFCD00055505

Key Documents

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Product Name

Climbazole, PESTANAL®, analytical standard

InChI key

OWEGWHBOCFMBLP-UHFFFAOYSA-N

InChI

1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

SMILES string

CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2ccnc2

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
NMR: suitable
gas chromatography (GC): suitable

mp

96-100 °C

suitability

passes test for identity (NMR)

application(s)

agriculture
environmental

format

neat

Quality Level

100

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Application

Climbazole may be used as a reference standard in the determination of climbazole in environmental samples and in samples of anti-dandruff shampoo using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Climbazole is an imidazole antifungal agent, which is widely used as an active ingredient in anti-dandruff (AD) shampoos since, it inhibits the microbial growth and improves skin barrier on scalp.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK7483
BCCH9771
BCCD3471
BCBT4575

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Yan-Wei Yang et al.
Wei sheng yan jiu = Journal of hygiene research, 34(5), 626-628 (2005-12-07)
A high performance liquid chromatography method was established for determination of antidangdruff agent salicylic acid,zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo on a C18 column using acetonitrile-metholaqueous solution (10 mmol/L KH2 PO4 and 5 mmol/L EDTANa2, pH is adjusted
Yasuna Kobayashi et al.
Biological & pharmaceutical bulletin, 25(1), 53-57 (2002-02-05)
To determine the effect of climbazole on hepatic microsomal cytochrome P450 (P450) and drug-metabolizing enzymes, four different P450 isoforms (CYP2B1, 3A2, 2E1, and 2C12) were examined in female Long-Evans rats. Treatment of rats with climbazole resulted in the induction of
Y Kobayashi et al.
The Journal of toxicological sciences, 26(3), 141-150 (2001-09-13)
We examined the effect of climbazole on the induction of rat hepatic microsomal cytochrome P450 (P450), and compared the induction potency with other N-substituted azole drugs such as clorimazole. We found that climbazole is found to be a potent inducer
C Coiffard et al.
Annales pharmaceutiques francaises, 57(5), 392-396 (1999-10-16)
We compared thermostability of various natural (sulfoprolamine and sodium usnate) or synthetic (climbazol and piroctone olamine) antidandruff agents in aqueous diluted solution at pH around 7. Thermodegradation of these solutions was studied by an isothermal method in thermostatically controlled ovens
Alex A Pérez-Rivera et al.
Mutation research, 672(1), 27-39 (2008-10-28)
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. A series of genotoxicity studies were performed to support the human safety of this azole antifungal drug. Climbazole was not mutagenic in the
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