39269
Linoleic acid
Synonym(s):
cis-9,cis-12-Octadecadienoic acid
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About This Item
Linear Formula:
CH3(CH2)4CH=CHCH2CH=CH(CH2)7CO2H
CAS Number:
Molecular Weight:
280.45
EC Number:
200-470-9
UNSPSC Code:
12352211
MDL number:
Beilstein/REAXYS Number:
1727101
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
InChI key
OYHQOLUKZRVURQ-HZJYTTRNSA-N
SMILES string
OC(CCCCCCC/C=C\C/C=C\CCCCC)=O
assay
≥98.0% (GC)
form
liquid
technique(s)
cell culture | mammalian: suitable
impurities
heavy metals, tested
refractive index
n20/D 1.466 (lit.)
bp
229-230 °C/16 mmHg (lit.)
mp
−5 °C (lit.)
density
0.902 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
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Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Analysis Note
microbiol contamination ≤ 1000 CFU/g
residual solvents (GLC-HS) conforms ICHQ3
residual solvents (GLC-HS) conforms ICHQ3
Biochem/physiol Actions
Linoleic acid increases cell proliferation and gene expression of PPARα and its target genes such as acyl-CoA oxidase in primary duck hepatocytes .
General description
Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
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Poonamjot Deol et al.
Gut microbes, 15(1), 2229945-2229945 (2023-07-04)
Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18:2 omega-6), which must be obtained from
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