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Merck
CN

46140

Cloxacillin sodium salt monohydrate

VETRANAL®, analytical standard

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About This Item

Empirical Formula (Hill Notation):
C19H17ClN3NaO5S · H2O
CAS Number:
7081-44-9
Molecular Weight:
475.88
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329757084
EC Number:
211-390-9
Beilstein/REAXYS Number:
5403885
MDL number:
MFCD00150735

Key Documents

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Product Name

Cloxacillin sodium salt monohydrate, VETRANAL®, analytical standard

InChI key

KCUWTKOTPIUBRI-VICXVTCVSA-M

InChI

1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

SMILES string

O.[Na].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c3c(C)onc3-c4ccccc4Cl)C(O)=O

grade

analytical standard

agency

EPA 1694

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

Quality Level

200

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ8987
BCCD9170
BCBW1061
BCBV3429
BCBT5530

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Chunyapuk Kukusamude et al.
Talanta, 92, 38-44 (2012-03-06)
An ion-paired extraction (IPE) has been developed for the analysis of penicillin antibiotics (penicillin G, oxacillin and cloxacillin) in beef and milk samples using tetrabutylammonium bromide (TBABr) as ion-pairing agent and binary water-acetonitrile as extractant. The factors affecting the IPE
[Native valve endocarditis due to Staphylococcus aureus].
Ignasi Rodríguez-Pintó et al.
Medicina clinica, 140(1), 48-48 (2012-06-30)
Srecko Marusic et al.
International journal of clinical pharmacology and therapeutics, 50(6), 431-433 (2012-06-09)
To present the case of warfarin-cloxacillin interaction that resulted in an increased international normalized ratio (INR). A 70-year-old man had been treated with warfarin for atrial fibrillation. He was hospitalized because of superficial thrombophlebitis of the left median cubital vein
[Treatment of resistant Gram-positive bacterial infections].
M Lenoble
Medecine et maladies infectieuses, 41(9 Suppl), 1-6 (2011-12-03)
Hossein Khalili et al.
European journal of clinical pharmacology, 69(3), 721-724 (2012-09-05)
Three patients were admitted to the Imam Hospital, Tehran, Iran with a diagnosis of bacterial endocarditis. The patients had indications for valve replacement surgery and anticoagulant therapy. The administration of cloxacillin reduced the effect of warfarin, and subsequent increases in
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