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Merck
CN

484407

1-Methoxy-2-propanol

greener alternative

≥99.5%

Synonym(s):

Propylene glycol methyl ether, Propyleneglycol monomethyl ether

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About This Item

Linear Formula:
CH3CH(OH)CH2OCH3
CAS Number:
107-98-2
Molecular Weight:
90.12
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
57651153
EC Number:
203-539-1
Beilstein/REAXYS Number:
1731270
MDL number:
MFCD00004537
Assay:
≥99.5%
Vapor pressure:
10.9 mmHg ( 25 °C)

Key Documents

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InChI key

ARXJGSRGQADJSQ-UHFFFAOYSA-N

InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3

SMILES string

CC(O)COC

vapor density

3.12 (vs air)

vapor pressure

10.9 mmHg ( 25 °C)

product line

ReagentPlus®

assay

≥99.5%

Quality Level

200

autoignition temp.

532 °F

expl. lim.

13.8 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
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impurities

≤0.001% water

mp

-97 °C

solubility

water: miscible

density

0.916 g/mL at 25 °C (lit.)

application(s)

microbiology

greener alternative category

, Aligned

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General description

1-Methoxy-2-propanol (Propylene glycol methyl ether, PGME), a glycol ether, can be synthesized by reacting propylene oxide with methanol in the presence of ZnMgAl (zinc-magnesium-aluminium) catalysts. Its degradation by microorganisms in different soil types has been investigated. An oral reference dose (RfD) and an inhalation reference concentration (RfC) values of PGME have been obtained from inhalation studies in F344 rats and B6C3F1 mice.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Monoethers, especially propylene glycol methyl ether (PGME), are widely used as pollution-free solvents in fine chemical synthesis in pharmaceutical, chemical and cosmetic industries and thus aligns with "Safer Solvents and Auxiliaries". Click here for more information.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

hcodes

H226,H336

Hazard Classifications

Flam. Liq. 3 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

88.7 °F - closed cup - (External MSDS)

flash_point_c

31.5 °C - closed cup - (External MSDS)

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SDBB6317
MKCZ6179
SDBB4845
SDBB2694
STBL4198

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Influence of acid-base properties of ZnMgAl-mixed oxides for the synthesis of 1-methoxy-2-propanol.
Cheng W, et al.
Applied Clay Science, 42(1), 111-115 (2008)
Biodegradation of glycol ethers in soil.
Gonsior SJ and West RJ.
Environmental Toxicology and Chemistry / Setac, 14(8), 1273-1279 (1995)
W R Berendsen et al.
Biotechnology and bioengineering, 95(5), 883-892 (2006-08-29)
Lipase-catalyzed kinetic resolution of racemates is a popular method for synthesis of chiral synthons. Most of these resolutions are reversible equilibrium limited reactions. For the first time, an extensive kinetic model is proposed for kinetic resolution reactions, which takes into
S R Vink et al.
Regulatory toxicology and pharmacology : RTP, 58(1), 64-71 (2010-04-17)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in
Juergen Brieger et al.
Toxicology letters, 177(2), 138-143 (2008-02-26)
To evaluate the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German
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