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484407

1-Methoxy-2-propanol

greener alternative

≥99.5%

Synonym(s):

Propylene glycol methyl ether, Propyleneglycol monomethyl ether

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About This Item

Linear Formula:
CH3CH(OH)CH2OCH3
CAS Number:
107-98-2
Molecular Weight:
90.12
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
57651153
EC Number:
203-539-1
Beilstein/REAXYS Number:
1731270
MDL number:
MFCD00004537
Assay:
≥99.5%
Bp:
118-119 °C (lit.)
Vapor pressure:
10.9 mmHg ( 25 °C)
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vapor density

3.12 (vs air)

Quality Level

200

vapor pressure

10.9 mmHg ( 25 °C)

product line

ReagentPlus®

assay

≥99.5%

autoignition temp.

532 °F

expl. lim.

13.8 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

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impurities

≤0.001% water

refractive index

n20/D 1.403 (lit.)

bp

118-119 °C (lit.)

mp

-97 °C

solubility

water: miscible

density

0.916 g/mL at 25 °C (lit.)

application(s)

microbiology

greener alternative category

, Aligned

SMILES string

CC(O)COC

InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3

InChI key

ARXJGSRGQADJSQ-UHFFFAOYSA-N

General description

1-Methoxy-2-propanol (Propylene glycol methyl ether, PGME), a glycol ether, can be synthesized by reacting propylene oxide with methanol in the presence of ZnMgAl (zinc-magnesium-aluminium) catalysts. Its degradation by microorganisms in different soil types has been investigated. An oral reference dose (RfD) and an inhalation reference concentration (RfC) values of PGME have been obtained from inhalation studies in F344 rats and B6C3F1 mice.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Monoethers, especially propylene glycol methyl ether (PGME), are widely used as pollution-free solvents in fine chemical synthesis in pharmaceutical, chemical and cosmetic industries and thus aligns with "Safer Solvents and Auxiliaries". Click here for more information.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

hcodes

H226,H336

Hazard Classifications

Flam. Liq. 3 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

88.7 °F - closed cup - (External MSDS)

flash_point_c

31.5 °C - closed cup - (External MSDS)

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB6317
MKCZ6179
SDBB4845
SDBB2694
STBL4198

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Influence of acid-base properties of ZnMgAl-mixed oxides for the synthesis of 1-methoxy-2-propanol.
Cheng W, et al.
Applied Clay Science, 42(1), 111-115 (2008)
S R Vink et al.
Regulatory toxicology and pharmacology : RTP, 58(1), 64-71 (2010-04-17)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in
Catherine Tomicic et al.
Analytical and bioanalytical chemistry, 396(7), 2709-2714 (2010-02-16)
Glycol ethers still continue to be a workplace hazard due to their important use on an industrial scale. Currently, chronic occupational exposures to low levels of xenobiotics become increasingly relevant. Thus, sensitive analytical methods for detecting biomarkers of exposure are
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Global Trade Item Number

SKUGTIN
484407-4L04061832391311
484407-18L04061832390628
484407-55GA04061838152350
484407-1L04061837369803
484407-2.5L04061832391267