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Merck
CN

50049

Glycine

BioUltra, ≥99.0% (NT)

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
EC Number:
200-272-2
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
635782
MDL number:
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product line

BioUltra

assay

≥99.0% (NT)

form

crystalline

impurities

Insoluble matter, passes filter test

ign. residue

≤0.05% (as SO4)

loss

≤0.05% loss on drying, 20 °C (HV)

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.)

solubility

1 M HCl: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤50 mg/kg

cation traces

Sr: ≤5 mg/kg, Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, NH4+: ≤200 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

λ

1 M in 1 M HCl

UV absorption

λ: 260 nm Amax: 0.01, λ: 280 nm Amax: 0.01

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

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Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Other Notes

Commonly used buffer substance in cryoenzymology; For osmotic pressure maintenance in isoelectric focusing of erythrocytes; In protein chemistry – salting-in effect; Growth requirement of various microorganisms.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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J K McGuire et al.
Journal of chromatography, 194(3), 323-333 (1980-06-27)
Several parameters that could affect the survival rate and the resolution of cells in continuous-flow isoelectric focusing have been investigated. Cell survival at progressively lower pHs was found to be a function of the osmolarity of the medium: at pH
CRC Handbook of Microbiology, 4, 1-1 (1974)
Cryoenzymology: the study of enzyme catalysis at subzero temperatures.
A L Fink et al.
Methods in enzymology, 63, 336-370 (1979-01-01)
Theory of protein solubility.
T Arakawa et al.
Methods in enzymology, 114, 49-77 (1985-01-01)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

Global Trade Item Number

SKUGTIN
568147-5G04061832880150
568147-1G04061826064702

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