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51082

Bromhexine hydrochloride

analytical standard

Synonym(s):

2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride, N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride, Bromohexine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H20Br2N2 · HCl
CAS Number:
611-75-6
Molecular Weight:
412.59
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329757666
EC Number:
210-280-8
Beilstein/REAXYS Number:
4848376
MDL number:
MFCD00056626
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Quality Level

100

grade

analytical standard

assay

98.0-102.0% (AT)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CN(Cc1cc(Br)cc(Br)c1N)C2CCCCC2

InChI

1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

InChI key

UCDKONUHZNTQPY-UHFFFAOYSA-N

Application

Bromhexine hydrochloride may be used as a reference standard in the determination of bromhexine hydrochloride in:
  • Cough-cold syrup using high performance liquid chromatography (HPLC).
  • Pharmaceutical formulations using gas liquid chromatography (GLC) and high performance liquid chromatography (HPLC).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9841
BCCK0296
BCCF3524
BCBZ9304
BCBW1688

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Gas-liquid chromatographic and ion-pair high-performance liquid chromatographic determination of pseudoephedrine hydrochloride and bromhexine hydrochloride in pharmaceuticals.
Rao V E, et al.
Analyst, 112(6), 871-874 (1987)
Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography.
Rauha P-J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 15(2), 287-293 (1996)
Ryusuke Kajihara et al.
International journal of pharmaceutics, 481(1-2), 132-139 (2015-02-11)
Multiple-unit tablets consisting of polymer-coated microgranules and excipients have a number of advantageous pharmaceutical properties. Polymer-coated microgranules are known to often lose their functionality because of damage to the polymer coating caused by tableting, and the mechanism of polymer coating

Global Trade Item Number

SKUGTIN
51082-100MG04061832491073