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Merck
CN

53541

Tulobuterol hydrochloride

VETRANAL®, analytical standard

Synonym(s):

2-tert-Butylamino-1-(2-chlorophenyl)ethanol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H18ClNO · HCl
CAS Number:
56776-01-3
Molecular Weight:
264.19
NACRES:
NA.24
PubChem Substance ID:
329757956
UNSPSC Code:
41116107
MDL number:
MFCD00214398

Key Documents

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Product Name

Tulobuterol hydrochloride, VETRANAL®, analytical standard

InChI

1S/C12H18ClNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H

SMILES string

Cl.CC(C)(C)NCC(O)c1ccccc1Cl

InChI key

RSLNRVYIRDVHLY-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

assay

≥98.0% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tulobuterol hydrochloride may be used as a reference standard in determining the concentration of tulobuterol hydrochloride present in bovine liver homogenates and urine samples using gas chromatography coupled with tandem mass spectrometry (GC-MS-MS).

General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706019, T706030, T706020
Tulobuterol hydrochloride is a sympathomimetic amine, possessing bronchodilator activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6694
BCCK9925
BCCH6222
BCCD9390
BCCC1945

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Shuwa Minami et al.
Internal medicine (Tokyo, Japan), 47(6), 503-509 (2008-03-18)
There is insufficient evidence for the efficacy of a transdermal tulobuterol patch (TP), although combination therapy with bronchodilators is recommended for chronic obstructive pulmonary disease (COPD). A randomized, controlled crossover study was conducted to evaluate the clinical efficacy and safety
Tetsuo Watanabe et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(10), 1483-1492 (2011-10-04)
The purpose of this study was to compare the transdermal transfer profiles of brand and generic tulobuterol patch formulations and to evaluate possible changes of in vivo kinetics resulting from increased transdermal transfer by means of pharmacokinetic analysis using reported
Ki-Seok Kim et al.
Colloids and surfaces. B, Biointerfaces, 76(2), 404-409 (2009-12-26)
In this work, porous poly(epsilon-caprolactone) (PCL)/Eudragit RS 100 (ERS-100) microcapsules containing tulobuterol base as a model drug were prepared by a solvent evaporation method and the effect of the quaternary ammonium groups of ERS-100 on the release behaviors of the
Chiyohiko Shindoh et al.
The Tohoku journal of experimental medicine, 218(4), 271-278 (2009-07-30)
Tulobuterol, a sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. Because diaphragm muscle weakness (i.e. decrease of contraction) is a feature of bronchial asthma and sepsis, we examined the in vitro and in vivo effects of
Tetsuya Abe et al.
Pulmonary pharmacology & therapeutics, 24(5), 617-624 (2011-06-22)
The addition of transdermal tulobuterol (Tulo) to inhaled tiotropium bromide (Tio) produced beneficial effects on spirometry-assessed parameters of respiratory function, disease-related symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD). To compare the effects of Tio
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