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3-Hydroxypicolinic acid

Name: 3-Hydroxypicolinic acid
Brand: SIAL

matrix substance for MALDI-MS, ≥99.0% (HPLC)

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Synonym(s):

3-HPA, 3-Hydroxypyridine-2-carboxylic acid

Empirical Formula (Hill Notation):

C₆H₅NO₃

CAS Number:

874-24-8

Molecular Weight:

139.11

Beilstein:

118954

EC Number:

212-859-0

MDL number:

MFCD00006294

PubChem Substance ID:

329758183

NACRES:

NA.21

grade

matrix substance for MALDI-MS

Quality Level

200

Assay

≥99.0% (HPLC)

form

powder or crystals

analyte chemical class(es)

oligonucleotides, oligosaccharides

technique(s)

MALDI-MS: suitable

mp

213-218 °C (lit.)

cation traces

Ba: ≤5 mg/kg
Ca: ≤50 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤20 mg/kg
K: ≤20 mg/kg
Mg: ≤50 mg/kg
Mn: ≤5 mg/kg
Na: ≤100 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤50 mg/kg

SMILES string

OC(=O)c1ncccc1O

InChI

1S/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)

InChI key

BRARRAHGNDUELT-UHFFFAOYSA-N

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Chromatography & Spectroscopy Reagents

Application

3-Hydroxypicolinic acid (3-HPA) is a matrix material used in matrix-assisted laser desorption/ionization (MALDI) based mass spectroscopy (MS) for the analysis of large biomolecules and quantification of oligonucleotides.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

3-Hydroxypicolinic acid has been used in the study conducted to isolate and characterize bacteria degrading-quinoline in subsurface sediments.

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Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Matrix-assisted laser desorption/ionization mass spectrometry of immobilized duplex DNA probes.

K Tang et al.

Nucleic acids research, 23(16), 3126-3131 (1995-08-25)

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry was used to analyze short DNA duplex probes with one strand immobilized on solid supports (straptavidin-coated magnetic beads or controlled pore glass beads). Only the non-immobilized strand could be detected. Partial denaturation

Utility of non-covalent complexes in the matrix-assisted laser desorption ionization mass spectrometry of heparin-derived oligosaccharides.

P Juhasz et al.

Carbohydrate research, 270(2), 131-147 (1995-04-30)

Molecular weights of heparin-derived oligosaccharides ranging from disaccharides to hexadecasaccharides have been determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. While these compounds ionize poorly or not at all when used as such, a strong signal can be obtained

Gas-phase diagnostics and LIF-imaging of 3-hydroxypicolinic acid MALDI-matrix plumes

Puretzky AA and Geohegan DB

Chemical Physics Letters, 286(5-6), 425-432 (1998)

Isolation and characterization of quinoline-degrading bacteria from subsurface sediments.

Applied and Environmental Microbiology, 55 (4), 1029-1032 (1989)

Accurate characterization of carcinogenic DNA adducts using MALDI tandem time-of-flight mass spectrometry.

Barnes C A and Chiu N H

International Journal of Mass Spectrometry, 279(2-3), 170-175 (2009)

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