58120
3-Iodo-L-tyrosine
≥99.0% (HPLC)
Synonym(s):
3-Monoiodo-L-tyrosine
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About This Item
Linear Formula:
IC6H3-4-(OH)CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
307.09
EC Number:
200-744-8
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2941266
MDL number:
eCl@ss:
32160406
assay
≥99.0% (HPLC)
optical activity
[α]20/D −3.1±0.3°, c = 2% in 0.1 M HCl
mp
204-208 °C (dec.), 210 °C (dec.) (lit.)
storage temp.
2-8°C
SMILES string
N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
InChI
1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChI key
UQTZMGFTRHFAAM-ZETCQYMHSA-N
Biochem/physiol Actions
Tyrosine hydroxylase inhibitor.
Other Notes
Inhibitor (Ki ~ 500 nM) of tyrosine hydroxylase
Regulatory Information
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G A Smythe et al.
The Journal of clinical endocrinology and metabolism, 40(4), 714-716 (1975-04-01)
Oral administration of a single 1 g dose of MIT to 10 normal male and female subjects resulted in a rise in serum prolactin in each subject. The mean peak level of serum prolactin attained by the 10 subjects was
K Painter et al.
Clinical chemistry, 25(5), 797-799 (1979-05-01)
Although there is abundant published evidence that radioiodinated antigens interfere in digoxin radioimmunoassays, other radioimmunoassays are similarly affected. We investigated the relationship of radioiodinated antigen structure to its function in the immunoassay. Carrier-free 125I-labeled iodotyrosine and iodohistamine derivatives were incubated
E E Müller et al.
Drugs, 25(4), 399-432 (1983-04-01)
Drugs whose systemic and/or central administration induce suppression or stimulation of prolactin secretion are reviewed. The most commonly used prolactin-lowering drugs include: (a) direct-acting dopamine receptor agonists (e.g. dopamine, apomorphine and the ergot derivatives); (b) indirect-acting dopamine agonists (e.g. amphetamine
M.K. Jain
Handbook of Enzyme Inhibitors, 362-362 (1982)
R. Shiman et al.
Methods in Enzymology, 17A, 609-609 (1970)
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