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60063

Potassium antimonyl tartrate trihydrate

99.0-103% (RT), purum p.a.

Synonym(s):

Antimony potassium tartrate trihydrate, Tartar emetic

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About This Item

Empirical Formula (Hill Notation):
C8H4K2O12Sb2 · 3H2O
CAS Number:
28300-74-5
Molecular Weight:
667.87
NACRES:
NA.21
PubChem Substance ID:
57651716
UNSPSC Code:
12352100
EC Number:
234-293-3
MDL number:
MFCD00167056
Assay:
99.0-103% (RT)
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Product Name

Potassium antimonyl tartrate trihydrate, purum p.a., 99.0-103% (RT)

grade

purum p.a.

Quality Level

200

assay

99.0-103% (RT)

loss

≤2.7% loss on drying

mp

≥300 °C (lit.)

anion traces

chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤500 mg/kg

cation traces

Ca: ≤50 mg/kg, Cd: ≤50 mg/kg, Co: ≤50 mg/kg, Cu: ≤50 mg/kg, Fe: ≤50 mg/kg, Na: ≤500 mg/kg, Ni: ≤50 mg/kg, Pb: ≤50 mg/kg, Zn: ≤50 mg/kg

SMILES string

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI key

WBTCZEPSIIFINA-UHFFFAOYSA-J

General description

Potassium antimonyl tartrate trihydrate is a trivalent antimony compound. It has been reported to be a leishmanicidal compound and exhibits more toxic action than pentavalent antimony (Pentostam) against Leishmania species. Three-dimensional X-ray and white radiation neutron diffraction methods have been reported to investigate the crystal structure of its optically active form (dipotassium di-μ-d-tartrato (4)-bis(antimonate(III)) trihydrate). Unit cell dimensions reported were: a = 11.192(2), b = 11.696(3), and c = 25.932(5)Å.

Application

Potassium antimonyl tartrate trihydrate may be used as an Sb(III)-containing drug to investigate its ability to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum.

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pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1703
BCCM8152
BCCL6745
BCCM4526
BCCH3297

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D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
D Sereno et al.
Antimicrobial agents and chemotherapy, 41(5), 972-976 (1997-05-01)
Using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide microassay, previously described as a means of quantifying Leishmania amazonensis in vitro at the amastigote stage (D. Sereno and J. L. Lemesre, Parisitol. Res., in press), we have compared the activities of seven drugs, including those
View All Related Papers

Global Trade Item Number

SKUGTIN
60063-250G04061832655758
60063-1KG04061826714782