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Merck
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α-Ketoglutaric acid

analytical standard

Synonym(s):

2-Oxoglutaric acid, 2-Oxopentanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
Molecular Weight:
146.10
EC Number:
206-330-3
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
1705689
MDL number:
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grade

analytical standard

assay

99.0-101.0% (T)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

General description

α-Ketoglutaric acid, an α-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling. It plays an important role in living beings as an angiogenesis suppressor.

Application

α-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Human plasma samples using gas-chromatography coupled to mass spectrometry.
  • Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
  • Fruits and vegetables using HPLC-MS/MS.



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Pictograms

Corrosion

Signal Word

Danger

Hazard Codes

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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